{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:19:55Z","timestamp":1778498395541,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Whereas early rhinophyma is histopathologically thought to resemble fully developed rosacea, a fibromatous variant has previously been described for severe rhinophyma. In terms of clinical characteristics, recently a new Rhinophyma Severity Index (<jats:styled-content style=\"fixed-case\">RHISI<\/jats:styled-content>) was introduced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 24 patients who had been treated with wide shave excisions for rhinophyma. Specimens were stained with hematoxylin\u2010eosin, periodic acid\u2010Schiff reaction and a panel of immunohistochemical stains and observed for any correlation between clinical severity and histopathologic features as well as for predictive markers of clinical recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant histopathologic differences between the groups reflecting the different clinical expressions. From a histopathologic perspective, clinically severe forms did not show with exclusive fibrotic changes. Further, there was no histopathologic marker predicting the clinical course or possible recurrence of the disease after surgical treatment. Only the clinical pre\u2010operative <jats:styled-content style=\"fixed-case\">RHISI<\/jats:styled-content> score correlated with the postoperative outcome, with a high pre\u2010operative <jats:styled-content style=\"fixed-case\">RHISI<\/jats:styled-content> being a risk factor for recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Histopathologic features do not correlate with the clinical expression of rhinophyma. An exclusively \u2018fibrotic\u2019 rhinophyma form does not appear to exist and could possibly be the result of sampling error based on small biopsies studied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12518","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T02:34:53Z","timestamp":1430966093000},"page":"527-535","source":"Crossref","is-referenced-by-count":25,"title":["Histopathology of rhinophyma\u00a0\u2013\u00a0a clinical\u2010histopathologic correlation"],"prefix":"10.1111","volume":"42","author":[{"given":"Monica","family":"Sch\u00fc\u00fcrmann","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Hospital of Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tino","family":"Wetzig","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Dermatosurgery and Allergology Asklepios Klinik Wei\u00dfenfels  Wei\u00dfenfels Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Wickenhauser","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Leipzig  Halle Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marita","family":"Ziepert","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology University of Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Kreuz","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Statistics and Epidemiology University of Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjana","family":"Ziemer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Hospital of Leipzig  Leipzig 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