{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:52:01Z","timestamp":1761630721205,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>A 37\u2010year\u2010old pregnant woman presented with a 2\u2010cm irregular reddish nodule on her left upper arm during pregnancy. A biopsy from the lesion showed a 2.2\u2010mm thick malignant melanoma with intravascular invasion, 25 mitosis\/mm<jats:sup>2<\/jats:sup> and no ulceration. Following induction of labor, the patient underwent re\u2010excision with sentinel lymph node biopsy. This showed no residual melanoma and no lymph node metastasis. The newborn boy had multiple pigmented lesions on the trunk, some of which were large and irregular. Two were biopsied and histologic examination showed dense dermal proliferation of medium sized melanocytes with multiple mitotic figures and no maturation with their descent into the dermis, raising suspicion of transplacental metastases. Examination of the placenta failed to show metastatic lesions. Multiplex polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>)\u2010based genotyping, including testing for amelogenin locus for sex chromosome determination, demonstrated the presence of Y chromosome material in the melanocytes of the newborn's lesions excluding maternal origin. A diagnosis of congenital nevi was rendered. Subsequently, Imaging Mass Spectrometric analysis of the mother's lesion showed proteomic signature expression indicative of malignant melanoma, whereas the two lesions in the newborn showed changes indicative of nevi. This case demonstrates the utility of genotyping and Mass Spectrometry analysis in this challenging clinical scenario<\/jats:p>","DOI":"10.1111\/cup.12523","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T13:53:19Z","timestamp":1431957199000},"page":"757-764","source":"Crossref","is-referenced-by-count":22,"title":["Congenital nevi versus metastatic melanoma in a newborn to a mother with malignant melanoma\u00a0\u2013\u00a0diagnosis supported by sex chromosome analysis and Imaging Mass Spectrometry"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3776-5053","authenticated-orcid":false,"given":"Ahmed K.","family":"Alomari","sequence":"first","affiliation":[{"name":"Department of Pathology Yale School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Earl J.","family":"Glusac","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale School of 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