{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:21:34Z","timestamp":1783171294428,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Several types of cutaneous reactions have been reported to arise at the site of herpes zoster (<jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>) infection weeks to years after the acute disease. Among these, granulomatous reactions are the most frequently reported. In this study, we describe the spectrum of histopathologic findings of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> granulomatous reactions observed in 26 patients with cutaneous lesions confined to the area of previous <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> eruption and compare them with biopsy specimens taken from 25 patients with acute <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>. All patients with persistent reactions from whom history was available presented within 12\u2009weeks of the onset of the acute eruption. The most frequent findings were interstitial granulomatous dermatitis with lymphocytes, histiocytes and multinucleated giant cells displaying elastophagocytosis and a perineural, perivascular and perieccrine mononuclear inflammatory infiltrate rich in lymphocytes and plasma cells. Less common features included intra\u2010arrector and peri\u2010arrector pili granulomas, follicular dilatation and hyperkeratosis, and vasculitis. Specimens from patients with acute <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> were found to have small numbers of perineural plasma cells and most had subtle granulomatous inflammation, in patterns similar to the group with late granulomatous reactions. Our findings suggest that granulomatous reactions to varicella zoster virus represent a persistent evolving inflammatory reaction after acute infection.<\/jats:p>","DOI":"10.1111\/cup.12531","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T11:08:46Z","timestamp":1431428926000},"page":"739-745","source":"Crossref","is-referenced-by-count":23,"title":["Herpes zoster granulomatous dermatitis: histopathologic findings in a case series"],"prefix":"10.1111","volume":"42","author":[{"given":"Katalin","family":"Ferenczi","sequence":"first","affiliation":[{"name":"Departments of Dermatology and Pathology MetroHealth Medical Center, Case Western Reserve University  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene S.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pathology MetroHealth Medical Center, Case Western Reserve University  Cleveland OH 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