{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:09:29Z","timestamp":1762506569507},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:00:00Z","timestamp":1434499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Rhabdomyomatous mesenchymal hamartoma (<jats:styled-content style=\"fixed-case\">RMH<\/jats:styled-content>) is a rare congenital malformation involving the dermis and subcutaneous tissue, of which there were 62 reported cases through 2014. We report <jats:styled-content style=\"fixed-case\">RMH<\/jats:styled-content> in two neonates presenting as a sacral skin tag. In both cases, magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) of the spine showed evidence of spinal dysraphism, including a lipomyelomeningocele and a tethered cord. Surgical repair of the defects was performed. Histopathologic examination of the skin tags showed a haphazard arrangement of mature skeletal muscle fibers and adnexal elements, consistent with <jats:styled-content style=\"fixed-case\">RMH<\/jats:styled-content>. The second patient also had a hemangioma on the sacrum and was diagnosed with <jats:styled-content style=\"fixed-case\">LUMBAR<\/jats:styled-content> (lower body hemangioma and other cutaneous defects, urogenital anomalies\/ulceration, myelopathy, bony deformities, anorectal\/arterial anomalies, and renal anomalies) syndrome, an association between cutaneous infantile hemangiomas of the lower body and regional congenital anomalies. The apparent association of paraspinal <jats:styled-content style=\"fixed-case\">RMH<\/jats:styled-content> with spinal dysraphism suggests that aberrant migration of mesodermally derived tissues (including skeletal muscle fibers) during neural tube development may be responsible for the pathologic findings in the skin. Additional study of patients with spinal dysraphism and congenital cutaneous lesions may further support this hypothesis.<\/jats:p>","DOI":"10.1111\/cup.12538","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T13:35:02Z","timestamp":1431956102000},"page":"774-778","source":"Crossref","is-referenced-by-count":15,"title":["Rhabdomyomatous mesenchymal hamartoma presenting as a sacral skin tag in two neonates with spinal dysraphism"],"prefix":"10.1111","volume":"42","author":[{"given":"Elizabeth L.","family":"McKinnon","sequence":"first","affiliation":[{"name":"Department of Pathology Duke University Medical Center  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Rand","sequence":"additional","affiliation":[{"name":"Department of Pathology Duke University Medical Center  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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