{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:05:37Z","timestamp":1788505537294,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Vulvar dermatoses are often difficult to classify due to histopathologic overlap. We aimed to report our experience at a single institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 183 non\u2010neoplastic, non\u2010infectious vulvar biopsies were reviewed. Associations between histopathologic features and specific diagnoses were analyzed by Chi\u2010squared tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two biopsies (12.0%) showed two concurrent processes. A limited differential rather than a definitive diagnosis was rendered in 15 cases (8.2%). The final diagnoses included lichen sclerosus (<jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>) (38.8%), lichen simplex chronicus (<jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content>) (29.0%), eczematous dermatitis (23.0%), Zoon vulvitis (8.2%), non\u2010specific\/resolved dermatitis (5.5%), hidradenitis suppurativa (2.7%), Beh\u00e7et disease (2.2%), lichen planus (1.6%), ruptured cyst (1.6%), ulcer not\u2010otherwise\u2010specified (1.6%), psoriasis (1.1%), radiation dermatitis (1.1%), sebopsoriasis (1.1%), seborrheic dermatitis (1.1%), epidermolytic hyperkeratosis (0.5%) and granular parakeratosis (0.5%). Early <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> and Zoon vulvitis were commonly included as part of a differential diagnosis. <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> was associated with <jats:italic>wiry collagen with lymphocyte entrapment<\/jats:italic> (p\u2009=\u20090.0188). <jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content> was associated with <jats:italic>zones of pale epithelium<\/jats:italic> (p\u2009=\u20090.0084), and often displayed <jats:italic>prominent fibroblasts<\/jats:italic> (p\u2009=\u20090.0555). Zoon vulvitis was frequently misdiagnosed, and was associated with <jats:italic>basal keratinocytic crowding<\/jats:italic> (p\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study has determined the relative frequencies of a wide variety of vulvar dermatoses, and identified new diagnostic clues for early <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content> and Zoon vulvitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12541","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T13:39:38Z","timestamp":1432215578000},"page":"510-518","source":"Crossref","is-referenced-by-count":67,"title":["Vulvar dermatoses: a histopathologic review and classification of 183 cases"],"prefix":"10.1111","volume":"42","author":[{"given":"May P.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Pathology and 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