{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:23:03Z","timestamp":1785684183281,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Background<\/jats:title>Desmoplastic trichoepithelioma (DTE<\/jats:styled-content>), morpheaform basal cell carcinoma (BCC<\/jats:styled-content>) and microcystic adnexal carcinoma (MAC<\/jats:styled-content>) are sclerosing adnexal neoplasms with overlapping histopathologic features. We compared cytokeratin 15, (CK15<\/jats:styled-content>), T\u2010cell death\u2010associated gene 51 (TDAG51<\/jats:styled-content>), cytokeratin 20 (CK20<\/jats:styled-content>) and androgen receptor (AR<\/jats:styled-content>) in differentiating these tumors and assessed their expression in BCC<\/jats:styled-content> subtypes.<\/jats:p><\/jats:sec>Methods<\/jats:title>Fifteen DTE<\/jats:styled-content>, 15 infundibulocystic BCC<\/jats:styled-content>, 18 micronodular BCC<\/jats:styled-content>, 18 morpheaform BCC<\/jats:styled-content> and 6 MAC<\/jats:styled-content> were assessed for CK15<\/jats:styled-content>, TDAG51<\/jats:styled-content>, CK20<\/jats:styled-content> and AR<\/jats:styled-content> expression.<\/jats:p><\/jats:sec>Results<\/jats:title>Quantitative CK15<\/jats:styled-content> staining was higher in DTE<\/jats:styled-content> compared with BCC<\/jats:styled-content> (p\u2009<\u20090.0001) and MAC<\/jats:styled-content> (p\u2009=\u20090.02). Quantitative TDAG51<\/jats:styled-content> staining was higher in DTE<\/jats:styled-content> than BCC<\/jats:styled-content> (p\u2009<\u20090.0001). The CK20<\/jats:styled-content>+AR<\/jats:styled-content>\u2212 immunophenotype was 100% sensitive and specific in diagnosing DTE<\/jats:styled-content>. The CK20<\/jats:styled-content>\u2212AR<\/jats:styled-content>+ immunophenotype was 95.24% specific and 83.33% sensitive for BCC<\/jats:styled-content>. The CK20<\/jats:styled-content>\u2212AR<\/jats:styled-content>\u2212 immunophenotype was 83.33% sensitive and 90.91% specific for MAC<\/jats:styled-content>. CK15<\/jats:styled-content>, CK20<\/jats:styled-content> and AR<\/jats:styled-content> were positive in 87, 53 and 67% of infundibulocystic BCC<\/jats:styled-content> cases, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Combination of CK20<\/jats:styled-content> and AR<\/jats:styled-content> best differentiated these sclerosing adnexal neoplasms. Greater positivity for CK15<\/jats:styled-content> and TDAG51<\/jats:styled-content> generally favors benign lesions. Infundibulocystic BCC<\/jats:styled-content> has higher CK20<\/jats:styled-content> and lower AR<\/jats:styled-content> immunopositivity than other BCC<\/jats:styled-content> variants and a high degree of CK15<\/jats:styled-content> and TDAG51<\/jats:styled-content> positivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12546","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T06:33:24Z","timestamp":1432794804000},"page":"824-831","source":"Crossref","is-referenced-by-count":38,"title":["Comparative analysis of cytokeratin 15, TDAG51, cytokeratin 20 and androgen receptor in sclerosing adnexal neoplasms and variants of\u00a0basal cell carcinoma"],"prefix":"10.1111","volume":"42","author":[{"given":"Mara Therese P.","family":"Evangelista","sequence":"first","affiliation":[{"name":"Departments of Dermatology and Pathology University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey 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