{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:39:35Z","timestamp":1777621175382,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Anaplastic lymphoma kinase (ALK) expression is uncommon in primary cutaneous T\u2010cell\u2010lymphomas (CTCL). We report the case of a patient who was initially diagnosed with small plaque parapsoriasis, and eventually developed an unusual manifestation of CTCL 6\u2009years later. The disease was characterized by aggressively ulcerating plaques and tumors of the entire skin. Histopathology revealed monoclonal proliferation of atypical T\u2010lymphocytes and CD30\u2010positive blasts with expression of ALK and identification of an ATIC\u2010ALK fusion protein. Extensive staging confirmed the primary cutaneous origin of the lymphoma. After failure of several conventional treatments including polychemotherapy, the patient finally achieved remission after receiving brentuximab\u2010vedotin, alemtuzumab and subsequent allogeneic stem cell transplantation. In the following, the patient developed inflammatory cutaneous lesions that pathologically showed no evidence for lymphoma relapse or classical cutaneous graft\u2010versus\u2010host disease. The patient responded to immunosuppression, but finally died from multi\u2010organ failure due to sepsis 8\u2009months after stem cell transplantation. This is a rare instance of ALK positivity in a CTCL, most likely resembling CD30+ transformed mycosis fungoides, because it was not typical for cutaneous anaplastic large cell lymphoma (ALCL). In contrast to its role in systemic ALCL as favorable prognostic marker, ALK expression here was associated with an aggressive course.<\/jats:p>","DOI":"10.1111\/cup.12547","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T13:58:55Z","timestamp":1433167135000},"page":"870-877","source":"Crossref","is-referenced-by-count":12,"title":["<scp>ALK<\/scp>\u2010positive primary cutaneous T\u2010cell\u2010lymphoma (<scp>CTCL<\/scp>) with unusual clinical presentation and aggressive course"],"prefix":"10.1111","volume":"42","author":[{"given":"Ulrike","family":"Wehkamp","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilske","family":"Oschlies","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section for Hematopathology University of Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga","family":"Nagel","sequence":"additional","affiliation":[{"name":"Department of Human Genetics University of Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Brasch","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kneba","sequence":"additional","affiliation":[{"name":"Medical Department II University of Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Division of Stem Cell Transplantation and Immunotherapy University of Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section for Hematopathology University of Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Weichenthal","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2012.06.010"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_4_4_1","first-page":"553","article-title":"Cutaneous peripheral T\u2010cell lymphomas, unspecified\/NOS and rare subtypes: a heterogeneous group of challenging cutaneous lymphomas","volume":"147","author":"Kempf W","year":"2012","journal-title":"G Ital Dermatol 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