{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:38:07Z","timestamp":1761709087595},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Atypical fibroxanthoma (AFX) is an uncommon cutaneous neoplasm of pleomorphic myofibroblast\u2010like cells. Diagnosis requires exclusion of other undifferentiated spindle and pleomorphic cell neoplasms by immunohistochemistry. We report two patients with p63\u2010non\u2010reactive spindle cell neoplasms which resembled AFX but demonstrated anomalous dot\u2010like immunolabeling with antibodies to high molecular weight keratin and keratin 5. One case recurred locally, suggesting such lesions may behave aggressively. Whether these lesions represent keratin\u2010positive dermal sarcomas or poorly differentiated carcinomas is debatable. Regardless of exact classification, our experience suggests such cases should be managed as high\u2010risk non\u2010melanoma skin cancers.<\/jats:p>","DOI":"10.1111\/cup.12548","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T10:58:39Z","timestamp":1433415519000},"page":"847-852","source":"Crossref","is-referenced-by-count":2,"title":["Pleomorphic spindle cell dermal neoplasm with dot\u2010like keratin reactivity: keratin\u2010positive AFX or carcinoma?"],"prefix":"10.1111","volume":"42","author":[{"given":"Ransom","family":"Ellis","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Division of Dermatology University of Kansas School of Medicine  Kansas City KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Chase","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Dermatology University of Kansas School of Medicine  Kansas City KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alycia","family":"Barland","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Dermatology University of Kansas School of Medicine  Kansas City KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Rajpara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Dermatology University of Kansas School of Medicine  Kansas City KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garth R.","family":"Fraga","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Division of Dermatology University of Kansas School of Medicine  Kansas City KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2012.01.001"},{"key":"e_1_2_4_3_1","first-page":"664","article-title":"Atypical Fibroxanthoma. 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