{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:38:01Z","timestamp":1789810681446,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T00:00:00Z","timestamp":1439164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The classic histopathologic features of lichen sclerosus et atrophicus (<jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>) include lymphoplasmacytic inflammation below a zone of dermal edema and sclerosis. The presence of eosinophils in <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> has received little attention, but the finding of tissue eosinophils, particularly eosinophilic spongiosis in <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>, has been suggested as a marker for the coexistence of autoimmune bullous disease or allergic contact dermatitis (or both). We sought to determine whether the histopathologic presence of dermal eosinophils or eosinophilic spongiosis (or both) in biopsies from patients with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> is associated with autoimmune bullous disease, autoimmune connective tissue disease or allergic contact dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of the histopathology and medical records of 235 patients with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content> who were evaluated from June 1992 to June 2012 was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010nine patients (29%) had eosinophils on histopathology. Among patients with associated diseases, a statistically significant association between the eosinophil cohort and the cohort without eosinophils was not detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The importance of eosinophils is uncertain, but our data suggest that the finding of tissue eosinophils alone is not sufficient to prompt an extensive workup for additional diagnoses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12556","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T08:44:00Z","timestamp":1436345040000},"page":"693-698","source":"Crossref","is-referenced-by-count":16,"title":["Eosinophils in lichen sclerosus et atrophicus"],"prefix":"10.1111","volume":"42","author":[{"given":"Phillip J.","family":"Keith","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Wolz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot S.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"},{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester MN 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