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There have been only 13 reports in the literature of primary cutaneous melanoma arising in dermal melanocytoses. We report a case of a Chinese woman with melanoma arising in a congenital nevus of Ito. We performed targeted next\u2010generation sequencing of the tumor which revealed mutations of <jats:italic><jats:styled-content style=\"fixed-case\">GNAQ<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">BAP1<\/jats:styled-content><\/jats:italic>, suggesting that alterations in these two genes led to malignant transformation of the nevus of Ito. We also provide a summary of reports in the literature regarding primary cutaneous melanoma arising in the context of dermal melanocytosis.<\/jats:p>","DOI":"10.1111\/cup.12568","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T05:35:01Z","timestamp":1439271301000},"page":"57-63","source":"Crossref","is-referenced-by-count":34,"title":["Melanoma arising in a nevus of Ito: novel genetic mutations and a review of the literature on cutaneous malignant transformation of dermal melanocytosis"],"prefix":"10.1111","volume":"43","author":[{"given":"Julie Y.","family":"Tse","sequence":"first","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke E.","family":"Walls","sequence":"additional","affiliation":[{"name":"Department of Dermatology Brigham &amp; Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyemin","family":"Pomerantz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Brigham &amp; 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