{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:25:17Z","timestamp":1778498717888,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T00:00:00Z","timestamp":1441238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous intraneural reactive epithelial proliferations mimicking malignancy include epithelial sheath neuroma, re\u2010excision perineural invasion and reactive neuroepithelial aggregates. Nevertheless, intraneural growth of benign sweat gland tumors has not been reported before.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To report a predominantly intraneural proliferation of morphologically bland sweat gland tumors, describe their clinicopathological features and correlate them with survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed a spiradenoma and a hidradenoma with a prominent intraneural growth, occurring on the back of the 19\u2010year\u2010old woman and on the arm of the 53\u2010year\u2010old woman. Both lesions presented as a painful and slightly raised papule. After complete excision, an uneventful clinical course was observed during the follow\u2010up period of 52 and 54 months. Pathologically, the most striking feature was an almost exclusive intraneural growth within the peripheral nerves of the deep dermis and subcutis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report for the first time the predominantly intraneural growth of benign sweat gland tumors. Although their histogenesis is unknown, perineural displacement due to previous surgery or trauma, as well as development from intraneural embryological epithelial remnants remains possibilities. Long\u2010term follow\u2010up of our patients suggests that intraneural growth of otherwise bland sweat gland tumors does not signify malignancy. Complete excision appears to be sufficient treatment procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12570","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T09:05:48Z","timestamp":1439283948000},"page":"878-883","source":"Crossref","is-referenced-by-count":8,"title":["Perineural growth of benign cutaneous sweat gland tumors: a hitherto unrecognized phenomenon unassociated with malignancy"],"prefix":"10.1111","volume":"42","author":[{"given":"Bo\u0161tjan","family":"Luzar","sequence":"first","affiliation":[{"name":"Institute of Pathology Medical Faculty University of Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Shanesmith","sequence":"additional","affiliation":[{"name":"Division of Dermatology East Carolina University  Greenville NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Calonje","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology St John's Institute of Dermatology, St Thomas' Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,3]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200002000-00004"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010215)91:4<804::AID-CNCR1067>3.0.CO;2-T"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200606000-00008"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2008.01068.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2012.01977.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182957bcc"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199002000-00010"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200006000-00019"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000211516.82983.e3"},{"key":"e_1_2_4_11_1","article-title":"Reactive neuroepithelial aggregates of the skin","volume":"205","author":"Chen KTK","year":"2003","journal-title":"Int J Surg Pathol"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181c70d88"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34412.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.12.403"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2012.01876.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/archderm.1979.04010080061029","article-title":"Trichofolliculoma showing perineural invasion. 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