{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:36:19Z","timestamp":1783488979393,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T00:00:00Z","timestamp":1442793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Classical Kaposi sarcoma (<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>) usually appears on lower extremities accompanied or preceded by local lymphedema. However, the development in areas of chronic lymphedema of the arms following mastectomy, mimicking a Stewart\u2013Treves syndrome, has rarely been described. We report an 81\u2010year\u2010old woman who developed multiple, erythematous to purple tumors, located on areas of post mastectomy lymphedema. Histopathological examination evidenced several dermal nodules formed by spindle\u2010shaped cells that delimitated slit\u2010like vascular spaces with some red cell extravasation. Immunohistochemically, the human herpesvirus type 8 (<jats:styled-content style=\"fixed-case\">HHV\u20108<\/jats:styled-content>) latent nuclear antigen\u20101 was detected in the nuclei of most tumoral cells confirming the diagnosis of <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>. Lymphedema could promote the development of certain tumors by altering immunocompetence. Although angiosarcoma (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) is the most frequent neoplasia arising in the setting of chronic lymphedema, other tumors such as benign lymphangiomatous papules (<jats:styled-content style=\"fixed-case\">BLAP<\/jats:styled-content>) or <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> can also develop in lymphedematous limbs. It is important to establish the difference between <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> because their prognosis and treatment are very different. Identification by immunohistochemistry of <jats:styled-content style=\"fixed-case\">HHV\u20108<\/jats:styled-content> is useful for the distinction between <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">BLAP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cup.12573","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T07:56:06Z","timestamp":1439366166000},"page":"889-893","source":"Crossref","is-referenced-by-count":5,"title":["Kaposi sarcoma following postmastectomy lymphedema"],"prefix":"10.1111","volume":"42","author":[{"given":"Iria","family":"Montero P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Dermatology and Pathology, Faculty of Medicine Complejo Hospitalario Universitario  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rodr\u00edguez\u2010Pazos","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pathology, Faculty of Medicine Complejo Hospitalario Universitario  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"\u00c1lvarez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pathology, Faculty of Medicine Complejo Hospitalario Universitario  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00aaMercedes Pereiro","family":"Ferreir\u00f3s","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pathology, Faculty of Medicine Complejo Hospitalario Universitario  Santiago de Compostela 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