{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:20:28Z","timestamp":1778498428774,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Although the histogenesis of sebaceous carcinomas remains unclear, the occurrence of intraepidermal or intraepithelial sebaceous carcinoma in the epidermis or conjunctiva may suggest <jats:italic>de novo<\/jats:italic> histogenesis. This report describes a case of sebaceous carcinoma within preexisting rippled\/carcinoid pattern sebaceoma. This lesion was composed of two (benign and malignant) components, and the benign component of the lesion showed the typical features of a rippled\/carcinoid pattern sebaceoma. Although evidence of trauma as well as a vertical orientation was seen in this lesion, the malignant component of the lesion showed histopathological evidence of malignancy (sebaceous carcinoma), such as the aggregations with irregular and infiltrated borders, a sheet\u2010like growth pattern, and the cytopathological findings of the neoplastic cells, showing a high\u2010grade of malignancy (a high mitotic index and abnormal mitotic figures). The immunohistochemical staining for p53, Ki\u201067 and <jats:styled-content style=\"fixed-case\">D2<\/jats:styled-content>\u201040 also favored this diagnosis. This sebaceous carcinoma component was considered to be the incipient stage of carcinoma within preexisting sebaceoma, therefore, it was still considered to be a vertically oriented lesion. This case shows the possibility that abnormal (malignant) sebaceous germinative cells may originate within a sebaceoma, thereby suggesting that some sebaceous carcinomas may develop from preexisting sebaceomas.<\/jats:p>","DOI":"10.1111\/cup.12575","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T08:58:17Z","timestamp":1439456297000},"page":"64-70","source":"Crossref","is-referenced-by-count":7,"title":["Sebaceous carcinoma within rippled\/carcinoid pattern sebaceoma"],"prefix":"10.1111","volume":"43","author":[{"given":"Noriyuki","family":"Misago","sequence":"first","affiliation":[{"name":"Division of Dermatology Nakao Clinic  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Toda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Saga University  Saga 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