{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:50:58Z","timestamp":1792381858162,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Background<\/jats:title>Confluent and reticulated papillomatosis (CRP<\/jats:styled-content>) is an uncommon dermatosis with a reticular pattern. As differentiation between CRP<\/jats:styled-content> and benign acanthosis nigricans (AN<\/jats:styled-content>) can be challenging because of their similar clinicopathological features, we aimed to distinguish the two diseases.<\/jats:p><\/jats:sec>Methods<\/jats:title>We retrospectively reviewed the clinical characteristics of 60 CRP<\/jats:styled-content> and 30 AN<\/jats:styled-content> patients. Histological examinations were conducted on 33 CRP<\/jats:styled-content> and 30 AN<\/jats:styled-content> lesions.<\/jats:p><\/jats:sec>Results<\/jats:title>While CRP<\/jats:styled-content> was concentrated on the trunk, AN<\/jats:styled-content> mostly appeared in the axilla. In the AN<\/jats:styled-content> group, the number of obese patients was higher, and acanthosis and papillomatosis were more evident. In both group, increases in Ki\u201067 and keratin 16 expression were similar. Bacterial infection was detected at a higher rate in CRP<\/jats:styled-content> lesions than in AN<\/jats:styled-content> lesions.AN<\/jats:styled-content> lesions had greater pigmentation because of a high number of melanocytes than CRP<\/jats:styled-content> lesions.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The location of skin lesions and body mass index are the main clinical factors that enable differentiation between CRP<\/jats:styled-content> and AN<\/jats:styled-content>. The epidermal histological changes in CRP<\/jats:styled-content> are milder than those in AN<\/jats:styled-content>. AN<\/jats:styled-content> lesions also showed a greater degree of pigmentation and melanocytic proliferation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12581","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T07:57:47Z","timestamp":1439366267000},"page":"944-952","source":"Crossref","is-referenced-by-count":10,"title":["Differentiating confluent and reticulated papillomatosis from acanthosis nigricans"],"prefix":"10.1111","volume":"42","author":[{"given":"Young Joon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010So","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Chan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200607050-00004"},{"key":"e_1_2_5_3_1","volume-title":"Weedon's skin pathology","author":"Weedon D","year":"2010"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00555.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5070\/D37MF6G290","article-title":"Acanthosis nigricans: a practical approach to evaluation and management","volume":"14","author":"Higgins SP","year":"2008","journal-title":"Dermatol Online J"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.04927.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01476.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06955.x"},{"key":"e_1_2_5_9_1","first-page":"xix","volume-title":"Lever's histopathology of the skin","author":"Lever WF","year":"2009"},{"key":"e_1_2_5_10_1","volume-title":"Lever's histopathology of the skin","author":"Lever WF","year":"2009"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04328.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/60.1.23"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.7570\/kjo.2014.23.1.64"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2008.20.2.94"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.016"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.6"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.132.3.381"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02696.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.2.276"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12219"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182819da6"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/archderm.1993.01680290033005","article-title":"Confluent and reticulated papillomatosis. 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