{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:27:26Z","timestamp":1780525646016,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:00:00Z","timestamp":1443484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oculocutaneous albinism (<jats:styled-content style=\"fixed-case\">OCA<\/jats:styled-content>) is a group of genetic disorders characterized by diminished pigmentation of the skin, hair and eyes. Individuals with <jats:styled-content style=\"fixed-case\">OCA<\/jats:styled-content> are at increased risk to develop sun\u2010induced skin malignancies. The incidence of malignant melanoma in <jats:styled-content style=\"fixed-case\">OCA<\/jats:styled-content> individuals is, however, very low. The aim of this study was to document pigmented and melanocytic skin lesions occurring in patients with <jats:styled-content style=\"fixed-case\">OCA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was performed. Sixteen patients with <jats:styled-content style=\"fixed-case\">OCA<\/jats:styled-content> presenting at the Oncology and Dermatology Departments at Universitas Academic Hospital Annex in Bloemfontein, South Africa, were included. Selected clinically pigmented and\/or melanocytic lesions were biopsied and studied by light microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four punch biopsies were taken. Ten dendritic freckles and 10 melanocytic nevi were confirmed histologically. The nevi, which occurred in eight patients, were found on sun\u2010protected skin. All the freckles occurred on sun\u2010exposed skin. Twelve patients had current or previous skin malignancies. No melanomas were present in the study population. Other skin lesions ranged from solar keratoses to squamous cell carcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of pigmented lesions were dendritic freckles that occurred on sun\u2010exposed skin. None of the patients had a current or previous diagnosis of malignant melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12588","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T09:09:04Z","timestamp":1439456944000},"page":"840-846","source":"Crossref","is-referenced-by-count":9,"title":["A histopathological study of melanocytic and pigmented skin lesions in patients with albinism"],"prefix":"10.1111","volume":"42","author":[{"given":"Gerhard","family":"van der Westhuizen","sequence":"first","affiliation":[{"name":"Department of Anatomical Pathology University of the Free State  Bloemfontein South Africa"},{"name":"National Health Laboratory Service  Bloemfontein South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Beukes","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology University of the Free State  Bloemfontein South Africa"},{"name":"National Health Laboratory 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