{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:38:55Z","timestamp":1761709135978},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"The precise classification and characterization of primary cutaneous gamma\u2010delta T\u2010cell lymphoma (PCGD\u2010TCL<\/jats:styled-content>) has been hindered by clinical and morphologic features that overlap with other lymphomas, especially subcutaneous panniculitis\u2010like T cell lymphoma (SPTCL<\/jats:styled-content>). The recent World Health Organization\/European Organization for Research and Treatment of Cancer (WHO<\/jats:styled-content>\/EORTC<\/jats:styled-content>) classification distinguishes the more aggressive PCGD\u2010TCL<\/jats:styled-content> from the usually indolent SPTCL<\/jats:styled-content>, however. We report a 30\u2010year\u2010old woman with an indurated violaceous plaque on the left cheek that had been present for several years. Biopsies showed a dense lymphocytic infiltrate involving the subcutis and dermis that consisted mostly of small and medium\u2010sized lymphocytes, some with irregular nuclear contours and dense chromatin. These cells were positive for TIA<\/jats:styled-content>\u20101, TCR<\/jats:styled-content>\u2010gamma and CD8<\/jats:styled-content>, but negative for beta\u2010F1<\/jats:styled-content> and granzyme\u2010B. Staging with positron emission tomography\u2013computed tomography (PET<\/jats:styled-content>\/CT<\/jats:styled-content>), CBC<\/jats:styled-content> and bone marrow with flow cytometry identified lymphadenopathy as well as blood and marrow involvement by an abnormal TCRgd<\/jats:styled-content>\u2010positive T\u2010cell proliferation (Ann Arbor Stage IV). The patient's history of a long\u2010standing lesion in this case is unusual, in that gamma\u2010delta T\u2010cell lymphomas are typically rapidly progressive neoplasms. As such, it raises the possibility of \u2018transformation\u2019 of a long\u2010standing inflammatory process into an overt lymphoma.<\/jats:p>","DOI":"10.1111\/cup.12591","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T08:29:23Z","timestamp":1439368163000},"page":"987-991","source":"Crossref","is-referenced-by-count":8,"title":["Gamma\u2010delta T\u2010cell lymphoma arising in a long\u2010standing cutaneous plaque"],"prefix":"10.1111","volume":"42","author":[{"given":"Liaqat","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Pathology The Penn State Hershey Medical Center Hershey PA USA"},{"name":"Department of Dermatology The Penn State Hershey Medical Center Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle R.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Pathology The William Beaumont Hospital Royal Oak MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Bayerl","sequence":"additional","affiliation":[{"name":"Department of Pathology The Penn State Hershey Medical Center Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus F.","family":"Helm","sequence":"additional","affiliation":[{"name":"Department of Pathology The Penn State Hershey Medical Center Hershey PA USA"},{"name":"Department of Dermatology The Penn State Hershey Medical Center Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren E.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Pathology The Penn State Hershey Medical Center Hershey PA USA"},{"name":"Department of Dermatology The Penn State Hershey Medical Center Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028005235.x"},{"key":"e_1_2_5_3_1","first-page":"302","volume-title":"WHO classification of tumors of hematopoietic and lymphoid tissue","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_5_4_1","first-page":"1723","article-title":"Non\u2010hepatosplenic \u03b3\/\u03b4 T cell lymphoma: a subset of cytotoxic T cell lymphoma with mucosal or skin localization","volume":"91","author":"Arnulf B","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_5_1","first-page":"1865","article-title":"Correlation of unique clinical, immunotypic and histologic findings in a cutaneous gamma\/delta T cell lymphoma","volume":"26","author":"Heald P","year":"1996","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200202000-00009"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.8.1052"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087288"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500051380"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000126719.71954.4f"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000187933.87103.03"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12591","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:01:17Z","timestamp":1696291277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,19]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/cup.12591"],"URL":"https:\/\/doi.org\/10.1111\/cup.12591","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,19]]}}}