{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:12:43Z","timestamp":1783807963652,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The rate of intravenous drug use (<jats:styled-content style=\"fixed-case\">IVDU<\/jats:styled-content>) has been increasing nationally; however, cutaneous manifestations of <jats:styled-content style=\"fixed-case\">IVDU<\/jats:styled-content> have infrequently been investigated. We report a series of the clinicopathological correlation of <jats:styled-content style=\"fixed-case\">IVDU<\/jats:styled-content> in the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search of surgical pathology files between the years 2000 and 2014 was performed for cutaneous specimens from patients with a reported history of <jats:styled-content style=\"fixed-case\">IVDU<\/jats:styled-content> for which the histopathological findings could not be attributed to another etiology. Ten cases for which slides were available were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients had an average age of 39.7\u2009years and had active or recent history of <jats:styled-content style=\"fixed-case\">IVDU<\/jats:styled-content>. Clinical impressions included ulcer, granulomatous dermatitis, vasculitis, pyoderma gangrenosum and hyperpigmentation at injection sites. Histopathology revealed leukocytoclastic vasculitis (n\u2009=\u20092), dermal pigment deposition (n\u2009=\u20093), non\u2010specific ulceration\/scarring (n\u2009=\u20094) and necrobiosis lipoidica\u2010like dermatitis (n\u2009=\u20091). No infectious etiology or polarizable foreign material was identified in any case.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cutaneous manifestations of <jats:styled-content style=\"fixed-case\">IVDU<\/jats:styled-content> should be considered in the differential as an etiology for dermatopathologic findings in high\u2010risk patients. We report histopathological findings beyond the scope of those most commonly associated with <jats:styled-content style=\"fixed-case\">IVDU<\/jats:styled-content>. We aim to raise awareness of the cutaneous manifestations of <jats:styled-content style=\"fixed-case\">IVDU<\/jats:styled-content> to improve clinicopathological correlation and patient management in light of the ongoing epidemic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12622","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T09:52:46Z","timestamp":1441705966000},"page":"815-823","source":"Crossref","is-referenced-by-count":13,"title":["Dermatopathologic manifestations of intravenous drug use"],"prefix":"10.1111","volume":"42","author":[{"given":"Julie Y.","family":"Tse","sequence":"first","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morayo","family":"Adisa","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne J.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology Boston Medical Center  Boston MA USA"},{"name":"Department of Pathology &amp; Laboratory Medicine Boston Medical Center  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalynn M.","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,9]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"United Nations Office on Drugs and Crime2014. 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