{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:23:03Z","timestamp":1785684183877,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T00:00:00Z","timestamp":1446076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Distinguishing porocarcinoma from squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) is clinically significant but can pose a diagnostic dilemma. The present study sought to confirm the diagnostic utility of <jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content> immunohistochemistry in distinguishing porocarcinoma from <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> and to examine histologic, carcinoembryonic antigen (<jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>) immunohistochemical and <jats:styled-content style=\"fixed-case\">CA19<\/jats:styled-content>\u20109 immunohistochemical differences between these tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunostaining with anti\u2010<jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content>, anti\u2010<jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> and anti\u2010<jats:styled-content style=\"fixed-case\">CA19<\/jats:styled-content>\u20109 antibodies was performed for 22 porocarcinomas and 31 <jats:styled-content style=\"fixed-case\">SCCs<\/jats:styled-content>. The extent of <jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CA19<\/jats:styled-content>\u20109 staining was classified as negative (&lt;1%), rarely positive (1\u20134%), focally positive (5\u201329%) or diffusely positive (30\u2013100%). <jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content> staining intensity was semi\u2010quantitatively graded as weak, moderate or strong.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All (100%) porocarcinomas were positive for <jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content>, with mainly focal (8\/22) or diffuse (11\/22) and moderate (9\/22) to strong (8\/22) staining. In contrast, only 6 of 31 <jats:styled-content style=\"fixed-case\">SCCs<\/jats:styled-content> (19.4%) expressed <jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content> focally, and this expression was limited to the basal layer of the tumor in four cases. <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> immunostaining highlighted the lumina of all 22 porocarcinomas; however, <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> expression was not significantly different between porocarcinomas and <jats:styled-content style=\"fixed-case\">SCCs<\/jats:styled-content> (100 vs. 71.0%, respectively). <jats:styled-content style=\"fixed-case\">CA19<\/jats:styled-content>\u20109 was not expressed in the lumina of 5 of 22 porocarcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Along with <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content> immunohistochemistry could be helpful in distinguishing porocarcinomas from <jats:styled-content style=\"fixed-case\">SCCs<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12632","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T09:34:40Z","timestamp":1444383280000},"page":"219-226","source":"Crossref","is-referenced-by-count":36,"title":["<scp>CD117<\/scp> (<scp>KIT<\/scp>) is a useful immunohistochemical marker for differentiating porocarcinoma from squamous cell carcinoma"],"prefix":"10.1111","volume":"43","author":[{"given":"Keisuke","family":"Goto","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kainan Hospital  Yatomi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Takai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hyogo Cancer Center  Akashi 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