{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:11:10Z","timestamp":1766268670025},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Plasmacytoid dendritic cells (<jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content>) belong to a subtype of dendritic cells that are normally absent in healthy skin. In some inflammatory diseases of the skin, especially lupus erythematosus (<jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>), these cells are occasionally recruited in great amounts, which can be used as a helpful clue for diagnosis. Rarely, <jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content> may also accumulate in the skin of patients with myeloid leukemia, a yet poorly known condition currently called \u2018tumor\u2010forming <jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content> associated with myeloid neoplasms\u2019. In this study, we describe a patient with unsuspected chronic myelomonocytic leukemia who developed cutaneous lesions characterized by a dermal infiltrate rich in <jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content>. Similarly to <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>, such neoplastic <jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content> were accompanied by interface dermatitis\u2010like changes, but displayed an aberrant phenotype and shared the same chromosomal abnormality with the leukemic cells identified in the bone marrow, thus revealing the neoplastic nature of the process. This observation illustrates that tumor\u2010forming <jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content> associated with myeloid neoplasms may microscopically mimic <jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content> in some patients. Accordingly, a hematologic workup is recommended in any skin lesion featuring excessive numbers of <jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content>, even if morphological alterations suggestive of interface dermatitis are found.<\/jats:p>","DOI":"10.1111\/cup.12639","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T10:46:58Z","timestamp":1444387618000},"page":"280-286","source":"Crossref","is-referenced-by-count":15,"title":["Tumor\u2010forming plasmacytoid dendritic cells associated with myeloid neoplasms. 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