{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:51:46Z","timestamp":1758981106087,"version":"3.37.3"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Cutaneous leiomyomata, which are benign smooth muscle neoplasms, commonly present as dermal\u2010based nodules or papules with smooth borders and firm consistency. Digital, particularly subungual leiomyomata are quite rare. A 16\u2010year\u2010old female presented to nail clinic complaining of discoloration of the lunula of the left thumbnail for 2.5\u2009months. On initial examination, a pink longitudinal band was present in the center of the nail plate, with yellow discoloration and distal onycholysis. The patient had only mild tenderness with firm palpation, and did not recall trauma of the area. A nail matrix biopsy was performed to determine the etiology of the lesion. Microscopic examination demonstrated a well\u2010demarcated dermal\u2010based spindle\u2010cell fascicular proliferation. Bland cells exhibited eosinophilic cytoplasm and elongate nuclei with blunt ends and minimal cytologic atypia. Prominent nucleoli, mitoses or necrosis were not appreciated. Immunohistochemical stains for smooth muscle actin and caldesmon highlighted the cells. Contrarily, S\u2010100, epithelial membrane antigen, p63, factor <jats:styled-content style=\"fixed-case\">XIIIa<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD34<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD68<\/jats:styled-content> and p75 were all negative. Ki\u201067 showed a low proliferative index. The immunoprofile combined with the morphologic features were interpreted as subungual leiomyoma. Subungual leiomyoma is a very rare diagnosis. We seek to bring awareness and expedite the diagnosis in patients with this lesion.<\/jats:p>","DOI":"10.1111\/cup.12645","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T07:14:46Z","timestamp":1446621286000},"page":"379-382","source":"Crossref","is-referenced-by-count":3,"title":["Subungual leiomyoma in the left thumb of a 16\u2010year\u2010old female"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1522-2541","authenticated-orcid":false,"given":"Miglena","family":"Komforti","sequence":"first","affiliation":[{"name":"Department of Pathology Duke University Medical Center  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Selim","sequence":"additional","affiliation":[{"name":"Department of Pathology Duke University Medical Center  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane S.","family":"Bellet","sequence":"additional","affiliation":[{"name":"Department of Dermatology Duke University Medical Center  Durham NC USA"},{"name":"Department of Pediatrics Duke University Medical Center  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01438_1.x"},{"volume-title":"Weedon's skin pathology","year":"2010","author":"Weedon D","key":"e_1_2_5_3_1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.48994"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03560.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.05.039"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)82043-9"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.04.051"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12645","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T05:29:43Z","timestamp":1695706183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,25]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/cup.12645"],"URL":"https:\/\/doi.org\/10.1111\/cup.12645","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2015,11,25]]}}}