{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:45:18Z","timestamp":1758980718132},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T00:00:00Z","timestamp":1455580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Asan Life Science Institute","award":["08-322"],"award-info":[{"award-number":["08-322"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have evaluated the histopathologic features of cutaneous extranodal natural killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>)\/T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">ENKTL<\/jats:styled-content>), and the histopathologic spectrum of this disease according to its clinical morphology remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigated the differences in pathologic findings of cutaneous <jats:styled-content style=\"fixed-case\">ENKTL<\/jats:styled-content> depending on clinical morphology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 41 cases of cutaneous <jats:styled-content style=\"fixed-case\">ENKTL<\/jats:styled-content> were included. Skin lesions were classified according to clinical morphology as: (i) nodular lesions, (ii) cellulitis or abscess\u2010like swellings and (iii) erythematous to purpuric patches. Histopathologic variables were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Perivascular infiltration of tumor cells and vasculopathy in the dermis and subcutaneous layer were common microscopic findings irrespective of clinical morphology. Erythematous to purpuric patches were mainly composed of small\u2010sized tumor cells, whereas medium\u2010 to large\u2010tumor cells were predominant in lesions of other clinical morphologies. The density of tumor cell infiltration was significantly higher in cellulitis or abscess\u2010like lesions or nodular lesions compared with erythematous to purpuric patches. A panniculitis\u2010like pattern and angiocentricity were less common in patch lesions than in cellulitis\u2010like swelling and nodular lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a histopathologic spectrum of cutaneous <jats:styled-content style=\"fixed-case\">ENKTL<\/jats:styled-content> that is dependent on the clinical morphology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12660","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T06:42:52Z","timestamp":1450852972000},"page":"324-333","source":"Crossref","is-referenced-by-count":8,"title":["Comparative histopathologic analysis of cutaneous extranodal natural killer\/T\u2010cell lymphomas according to their clinical morphology"],"prefix":"10.1111","volume":"43","author":[{"given":"Woo Jin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Hye","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong Hyun","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Eun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee Chan","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan\u2010Sik","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V89.11.3909","article-title":"A clinical evaluation of the international lymphoma study group classification of non\u2010Hodgkin's lymphoma. 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