{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:21:00Z","timestamp":1788373260966,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T00:00:00Z","timestamp":1455062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Pathology and Immunology Internal Research Grant Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"\n Background<\/jats:title>\n \n The\n GATA<\/jats:styled-content>\n family of transcription factors is an essential regulator of cellular proliferation and differentiation. In the skin,\n GATA<\/jats:styled-content>\n \u20103 is critical for epidermal stratification and maintenance of barrier function. A role for\n GATA<\/jats:styled-content>\n \u20103 in the development of human cutaneous squamous cell carcinoma (\n SCC<\/jats:styled-content>\n ) is not known. Here, we investigated\n GATA<\/jats:styled-content>\n \u20103 immunohistochemical staining in premalignant and invasive cutaneous\n SCC<\/jats:styled-content>\n from sun\u2010exposed and sun\u2010protected skin.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n GATA<\/jats:styled-content>\n \u20103 immunohistochemistry was performed on actinic keratoses (\n AK<\/jats:styled-content>\n ) (n\u2009=\u200919),\n in situ<\/jats:italic>\n squamous cell carcinomas with actinic [\n SCCIS<\/jats:styled-content>\n (A)] (n\u2009=\u20099) or bowenoid features [\n SCCIS<\/jats:styled-content>\n (B)] (n\u2009=\u200917), well\u2010, moderately and poorly differentiated\n SCC<\/jats:styled-content>\n (n\u2009=\u200936), Bowenoid papulosis of the perineum (n\u2009=\u200915) and penile\n SCC<\/jats:styled-content>\n (\n pSCC<\/jats:styled-content>\n ) (n\u2009=\u200910).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We found that\n GATA<\/jats:styled-content>\n \u20103 immunohistochemical staining is progressively lost in sun\u2010exposed skin as neoplasia progresses from pre\u2010cancerous\n AK<\/jats:styled-content>\n to\n SCCIS<\/jats:styled-content>\n (A), and ultimately, to\n SCC<\/jats:styled-content>\n , which shows near absent\n GATA<\/jats:styled-content>\n \u20103 staining. This reduction in\n GATA<\/jats:styled-content>\n \u20103 staining is independent of histological grade in\n SCC<\/jats:styled-content>\n . Only slight down\u2010regulation of\n GATA<\/jats:styled-content>\n \u20103 was seen in all cases of\n SCCIS<\/jats:styled-content>\n (B) and Bowenoid papulosis, while near absent\n GATA<\/jats:styled-content>\n \u20103 expression was seen in\n pSCC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n We propose that decreased\n GATA<\/jats:styled-content>\n \u20103 immunohistochemical staining is associated with cutaneous SCC progression on both sun\u2010exposed and sun\u2010protected sites.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cup.12667","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T22:20:56Z","timestamp":1452723656000},"page":"347-353","source":"Crossref","is-referenced-by-count":16,"title":["Cutaneous squamous cell carcinoma progression is associated with decreased\n GATA<\/scp>\n \u20103 immunohistochemical staining"],"prefix":"10.1111","volume":"43","author":[{"given":"Jason F.","family":"Solus","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine in St. Louis St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine in St. Louis St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Internal Medicine Division of Dermatology Washington University School of Medicine in St. Louis St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy C.","family":"Hsi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine in St. Louis St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana S.","family":"Rosman","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine in St. Louis St. Louis MO USA"},{"name":"Internal Medicine Division of Dermatology Washington University School of Medicine in St. Louis St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadmehr","family":"Dehmeri","sequence":"additional","affiliation":[{"name":"Internal Medicine Division of Dermatology Washington University School of Medicine in St. Louis St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Schaffer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine in St. Louis St. Louis MO USA"},{"name":"Internal Medicine Division of Dermatology Washington University School of Medicine in St. Louis St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.11.037"},{"key":"e_1_2_5_3_1","first-page":"39","article-title":"Management of high\u2010risk cutaneous squamous cell carcinoma","volume":"3","author":"Jennings L","year":"2010","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0157-RA"},{"key":"e_1_2_5_5_1","volume-title":"Textbook of penile cancer","author":"Heideman D a 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