{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:03:19Z","timestamp":1769263399823,"version":"3.49.0"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Frozen section is a valuable tool that is often underutilized in the setting of in\u2010patient dermatology. Traditionally, frozen section has been used in dermatology to diagnose toxic epidermal necrolysis, with some additional utility in staphylococcal scalded skin syndrome in the new born period. We report a newborn female with ruptured bullae on the face, chest, back and extremities with a clinical differential diagnosis that included staphylococcal scalded skin, bullous congenital ichthyosiform erythroderma\/epidermolytic hyperkeratosis and epidermolysis bullosa. A thin detached skin sample (\u2018jelly\u2010roll\u2019) taken from a ruptured bulla on the abdomen was prepared for frozen section analysis. Characteristic findings of epidermolytic hyperkeratosis were seen which included hyperkeratosis with granular layer degeneration, vacuolization and eosinophilic globules. The \u2018jelly\u2010roll\u2019 technique can be used for quick diagnosis with minimal trauma to the patient. Epidermolytic hyperkeratosis was subsequently confirmed by a biopsy fixed in formalin and by genetic testing. A novel missense mutation in<jats:styled-content style=\"fixed-case\">KRT1<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">I479N<\/jats:styled-content>) was identified. Herein, we discuss the use of the frozen section \u2018jelly roll\u2019 technique for rapid diagnosis in a case of bullous congenital ichthyosis erythroderma\/epidermolytic hyperkeratosis.<\/jats:p>","DOI":"10.1111\/cup.12680","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T07:12:01Z","timestamp":1457766721000},"page":"434-437","source":"Crossref","is-referenced-by-count":7,"title":["Use of the frozen section \u2018jelly\u2010roll\u2019 technique to aid in the diagnosis of bullous congenital ichthyosiform erythroderma (epidermolytic hyperkeratosis)"],"prefix":"10.1111","volume":"43","author":[{"given":"Blake","family":"Galler","sequence":"first","affiliation":[{"name":"Department of Dermatology Wilford Hall Ambulatory Surgical Center Lackland AFB TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey","family":"Bowen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wilford Hall Ambulatory Surgical Center Lackland AFB TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Arnold","sequence":"additional","affiliation":[{"name":"Micrographic Surgery and Dermatologic Oncology Vanderbilt University Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wilford Hall Ambulatory Surgical Center Lackland AFB TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott R.","family":"Dalton","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wilford Hall Ambulatory Surgical Center Lackland AFB TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,4]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00746.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/archderm.1975.01630230035004","article-title":"Toxic epidermal necrolysis: rapid differentiation between staphylococcal\u2010 and drug\u2010induced disease","volume":"111","author":"Amon RB","year":"1975","journal-title":"Arch Dermatol"},{"key":"e_1_2_4_4_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/B978-1-4160-9976-5.10020-3","volume-title":"Dermatopathology: a volume in the high yield pathology series","author":"Brinster NK","year":"2011"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690080092014"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116193"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117132"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181614898"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01555.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12680","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T23:49:39Z","timestamp":1718408979000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,4]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/cup.12680"],"URL":"https:\/\/doi.org\/10.1111\/cup.12680","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,4]]}}}