{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T22:27:43Z","timestamp":1749421663633},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Rheumatoid vasculitis (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) is one of the most serious extra\u2010articular complications of rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>), generally treated with a high dose of immunosuppressive drugs. Recently, we encountered two cases of ulcerative vasculitis in methotrexate (<jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>)\u2010prescribed <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients, which simulated <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>; however, Epstein\u2013Barr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>)\u2010encoded <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> <jats:italic>in situ<\/jats:italic> hybridization on their skin biopsies revealed many <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive lymphocytes (over 50 cells\/high\u2010power field) within the vessel walls and perivascular stroma, which led us to the diagnosis of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010related vasculitis instead of <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>. Subsequently, both ulcers regressed after the discontinuation of <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content> and no recurrence was noted during the follow\u2010up period. To prevent unnecessary treatment, <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive vasculitis should be added in the differential diagnosis of lymphocytic vasculitis observed in <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\u2010administered <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/cup.12690","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T08:20:47Z","timestamp":1457511647000},"page":"520-525","source":"Crossref","is-referenced-by-count":7,"title":["Methotrexate\u2010associated <scp>EBV<\/scp>\u2010positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis"],"prefix":"10.1111","volume":"43","author":[{"given":"Masakazu","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yo","family":"Kaku","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Ohmura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsuko","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneyo","family":"Mimori","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Haga","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket326"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000126"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37715"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04933.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2003.300101.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199802)41:2<369::AID-ART22>3.0.CO;2-S"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.95"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.07.029"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(72)80005-4"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181fd8781"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.10.4099"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03584.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740600902403"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000218356"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1741-1"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.2770"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.2593"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200109000-00001"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12644"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf8622"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130270"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-6-916_1"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310915"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02030360"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02238776"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.5.535"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02247805"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1293"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.3.190"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70231-3"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12690","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T19:25:56Z","timestamp":1695756356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,18]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/cup.12690"],"URL":"https:\/\/doi.org\/10.1111\/cup.12690","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,18]]}}}