{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:28:49Z","timestamp":1773937729008,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T00:00:00Z","timestamp":1459814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Atypical fibroxanthoma (<jats:styled-content style=\"fixed-case\">AFX<\/jats:styled-content>) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid and pleomorphic cells. Clinically, <jats:styled-content style=\"fixed-case\">AFX<\/jats:styled-content> is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of <jats:styled-content style=\"fixed-case\">AFX<\/jats:styled-content>, with only 13 cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear cells, such as squamous cell carcinoma, basal cell carcinoma, metastatic renal cell carcinoma and balloon cell malignant melanoma. These diagnoses can be ruled out by the typical immunohistochemical profile of clear cell <jats:styled-content style=\"fixed-case\">AFX<\/jats:styled-content>, which is negative for specific epithelial and melanocytic markers. Herein, we describe a rare and unusual case of clear cell <jats:styled-content style=\"fixed-case\">AFX<\/jats:styled-content> arising on the ear of a relatively young adult patient. Histologically, the dermis was completely replaced by an atypical population of vacuolated cells with numerous atypical mitoses. Immunohistochemical stains were negative forpancytokeratin, <jats:styled-content style=\"fixed-case\">CK5<\/jats:styled-content>\/6, CK7, and p63 <jats:styled-content style=\"fixed-case\">S100<\/jats:styled-content> and Melan\u2010A stains. <jats:styled-content style=\"fixed-case\">CD10<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD68<\/jats:styled-content> stains were positive, making the findings consistent with the diagnosis of clear cell atypical fibroxanthoma.<\/jats:p>","DOI":"10.1111\/cup.12696","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T08:34:44Z","timestamp":1457512484000},"page":"538-542","source":"Crossref","is-referenced-by-count":15,"title":["Clear cell atypical fibroxanthoma: a case report and review of the literature"],"prefix":"10.1111","volume":"43","author":[{"given":"Catherine M.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Irvine School of Medicine University of California  Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kaiser Permanente, Sunset Medical Center  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cassarino","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kaiser Permanente, Sunset Medical Center  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,5]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"FD09","article-title":"Clear cell atypical fibroxantoma: a rare variant of atypical fibroxanthoma and review of the literature","volume":"8","author":"Bedir R","year":"2014","journal-title":"J Clin Diagnost Res"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2012.01.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197306)31:6<1541::AID-CNCR2820310635>3.0.CO;2-6"},{"key":"e_1_2_5_5_1","volume-title":"Dermatology essentials","author":"Bolognia J"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1987.tb00919.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01843.x"},{"key":"e_1_2_5_8_1","first-page":"11","article-title":"Ultraviolet\u2010induced p53 mutations in atypical fibroxanthoma","volume":"145","author":"Dei Tos AP","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.22128"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860115)57:2<368::AID-CNCR2820570230>3.0.CO;2-N"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb15062.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1997.tb00670.x"},{"key":"e_1_2_5_13_1","first-page":"183","article-title":"Atypical fibroxanthoma of the skin. 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