{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:37:55Z","timestamp":1789609075119,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Background<\/jats:title>Mycosis fungoides\/S\u00e9zary syndrome (MF<\/jats:styled-content>\/SS<\/jats:styled-content>) often requires multiple skin biopsies for definitive diagnosis. In vivo<\/jats:italic> reflectance confocal microscopy (RCM<\/jats:styled-content>) visualizes high\u2010resolution cellular detail of the skin. The objective of this study is to evaluate the morphologic features of MF<\/jats:styled-content>\/SS<\/jats:styled-content> using RCM<\/jats:styled-content> and to correlate RCM<\/jats:styled-content> features with histopathology and T\u2010cell receptor (TCR<\/jats:styled-content>) gene rearrangement studies.<\/jats:p><\/jats:sec>Methods<\/jats:title>A cohort of patients with active\/recurrent or suspicious MF<\/jats:styled-content>\/SS<\/jats:styled-content> disease was prospectively recruited for RCM<\/jats:styled-content> imaging and histopathologic\/RCM<\/jats:styled-content> images were evaluated. Statistical analyses were performed to identify unique RCM<\/jats:styled-content> features and to correlate RCM<\/jats:styled-content> features with histopathologic findings and TCR<\/jats:styled-content> rearrangement studies.<\/jats:p><\/jats:sec>Results<\/jats:title>Eighty\u2010three lesions were evaluated. Correlation between RCM<\/jats:styled-content> and histopathology was moderate for all relatable features (\u03ba = 0.41, p<0.001), almost perfect for intraepidermal atypical lymphocytes [prevalence and bias\u2010adjusted kappa (PABAK<\/jats:styled-content>) = 0.90], and fair for Pautrier collections (\u03ba = 0.32, p = 0.03). Lesions with Pautrier collections identified by RCM<\/jats:styled-content> were significantly more likely to show TCR<\/jats:styled-content> clonality (p = 0.04) and diagnostic features of MF<\/jats:styled-content>\/SS<\/jats:styled-content> on histopathology (p = 0.03).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our study captures morphologic RCM<\/jats:styled-content> criteria for a variety of skin lesions. Pautrier collections visualized by RCM<\/jats:styled-content> are associated with improved histopathologic diagnosis and detection of TCR<\/jats:styled-content> gene clonality. Although further studies are needed to validate the diagnostic implications of RCM<\/jats:styled-content> for MF<\/jats:styled-content>\/SS<\/jats:styled-content>, our study highlights the potential utility of RCM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12708","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T07:28:08Z","timestamp":1457767688000},"page":"505-515","source":"Crossref","is-referenced-by-count":28,"title":["Reflectance confocal microscopy features of mycosis fungoides and S\u00e9zary syndrome: correlation with histopathologic and T\u2010cell receptor rearrangement studies"],"prefix":"10.1111","volume":"43","author":[{"given":"Silvia E.","family":"Mancebo","sequence":"first","affiliation":[{"name":"Department of Medicine, Dermatology Service Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Cordova","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology Service Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia L.","family":"Myskowski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology Service Memorial Sloan Kettering Cancer Center New York NY USA"},{"name":"Department of Dermatology Weill Cornell Medical College New York NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen S.","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology Service Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Busam","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering 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Medicine, Dermatology Service Memorial Sloan Kettering Cancer Center New York NY USA"},{"name":"Department of Pathology and Dermatology City of Hope Comprehensive Cancer Center Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1182\/asheducation.V2009.1.523.0010523","article-title":"The 2008 WHO classification of lymphomas: implications for clinical practice and translational research","volume":"2009","author":"Jaffe ES","journal-title":"Hematology Am Soc Hematol Educ 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