{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:29:35Z","timestamp":1758709775099,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T00:00:00Z","timestamp":1461110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Keratoacanthoma (<jats:styled-content style=\"fixed-case\">KA<\/jats:styled-content>) is a common keratinocytic skin neoplasm that typically develops rapidly and undergoes complete spontaneous regression. As the pro\u2010apoptotic p53 protein may be involved in the lifecycle of <jats:styled-content style=\"fixed-case\">KA<\/jats:styled-content>, we studied the p53 status throughout the main stages of <jats:styled-content style=\"fixed-case\">KA<\/jats:styled-content> that include proliferation, maturation and regression in a large series of lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010hundred and twenty\u2010four KAs were characterized with respect to age of the lesions both clinically and histopathologically, in addition to phenotypic characteristics such as cellular atypia, infiltration, inflammation and fibrosis. <jats:italic>Tp53<\/jats:italic> mutations were detected by capillary electrophoresis, and p53 protein levels were assessed by immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Tp53<\/jats:italic> mutations were detected in 49 cases (39.5%) and were associated with high p53 protein levels (p = 0.007) and histopathologic age of the lesions (p = 0.044). Significant association was also seen between high p53 protein levels and atypia (p = 0.036), whereas the association with infiltration showed borderline significance (p = 0.057). High p53 protein levels were significantly associated with gene mutations in transplanted, but not in non\u2010transplanted patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We show a high frequency of <jats:italic>Tp53<\/jats:italic> mutations in <jats:styled-content style=\"fixed-case\">KAs<\/jats:styled-content> that is associated with increased p53 levels. The results indicate a role for the p53 protein in KA development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12713","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T01:42:23Z","timestamp":1459302143000},"page":"571-578","source":"Crossref","is-referenced-by-count":5,"title":["<i>Tp53<\/i>\/p53 status in keratoacanthomas"],"prefix":"10.1111","volume":"43","author":[{"given":"Sarita","family":"Joshi","sequence":"first","affiliation":[{"name":"Department of Pathology Oslo University Hospital, Rikshospitalet  Oslo Norway"},{"name":"Institute of clinical medicine, Department of Pathology Akershus University Hospital  L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aasa R.","family":"Schj\u00f8lberg","sequence":"additional","affiliation":[{"name":"Department of Pathology Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per 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