{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:51:12Z","timestamp":1778125872314,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,8]],"date-time":"2016-05-08T00:00:00Z","timestamp":1462665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Monoclonal antibodies against the immune checkpoint programmed cell death receptor 1 (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101) improve the hosts' antitumor immune response and have showed tremendous promise in the treatment of advanced solid tumors and hematologic malignancies. Reports of serious autoimmune dermatologic toxicities from immune checkpoint blockade therapy, however, are emerging. We report our experience with five patients who presented with pruritic vesicles and blisters on the skin while treated with anti\u2010<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101 antibody immunotherapy with either nivolumab or pembrolizumab. Four of the patients' skin biopsies revealed subepidermal bullae with immunohistochemical study for type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> collagen labeling the floor of the blister cavity and direct immunofluorescence studies (in three of the four patients tested) decorated linear <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">C3<\/jats:styled-content> immune deposits on the blister roof, diagnostic of bullous pemphigoid. One patient developed bullous erythema multiforme. All patients had partial or complete resolution of skin lesions following treatment with systemic corticosteroid and cessation of checkpoint blockade. Recognition and treatment of rare immune\u2010related bullous dermatologic toxicities will become increasingly important as more patients are treated with effective and newer immune checkpoint blockade therapy.<\/jats:p>","DOI":"10.1111\/cup.12717","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T06:25:23Z","timestamp":1460960723000},"page":"688-696","source":"Crossref","is-referenced-by-count":121,"title":["Autoimmune dermatologic toxicities from immune checkpoint blockade with anti\u2010<scp>PD<\/scp>\u20101 antibody therapy: a report on bullous skin eruptions"],"prefix":"10.1111","volume":"43","author":[{"given":"George","family":"Jour","sequence":"first","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella C.","family":"Glitza","sequence":"additional","affiliation":[{"name":"Department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Texas Medical School  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Torres\u2010Cabala","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston TX USA"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Tetzlaff","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Texas Medical School  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyadharsini","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Auris","family":"Huen","sequence":"additional","affiliation":[{"name":"Department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyu P.","family":"Aung","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doina","family":"Ivan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston TX USA"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol R.","family":"Drucker","sequence":"additional","affiliation":[{"name":"Department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor G.","family":"Prieto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston TX USA"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald P.","family":"Rapini","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston TX USA"},{"name":"Department of Dermatology University of Texas Medical School  Houston TX USA"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anisha","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Texas Medical School  Houston TX USA"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan L.","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD 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