{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:35:00Z","timestamp":1785767700447,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Cutaneous clear cell hidradenoma is an uncommon benign adnexal tumor which is not supposed to metastasize, contrary to its rare malignant counterpart, hidradenocarcinoma. We report the case of a 49\u2010year\u2010old man, who had had a stable inguinal lymph node enlargement for 6 years. An excision was performed and revealed an intra\u2010nodal tumor, made of large clear cells with abundant cytoplasm and round nuclei without atypia or mitosis. The immunohistochemical staining showed diffuse positivity for keratin AE1\/AE3, keratin 5\/6 and p63, and focal staining with keratin 7, epithelial membrane antigen (EMA) and carcinous epithelial antigen (CEA), which underlined some ductular structures. Tumor cells were negative for renal markers PAX8 and CD10. Ki67 stained less than 1% of tumor cells. A translocation involving <jats:italic>MAML2<\/jats:italic> gene was evidenced by fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH) analysis. No primary cutaneous tumor was found after extensive examination. Altogether, these results are in favor of an isolated nodal hidradenoma, for which we discuss two hypothesis: a primary nodal lesion, or a \u2018benign metastasis\u2019 of a cutaneous tumor. Cases of morphologically benign hidradenoma with lymph node involvement are exceptional. Our case, similar to every other reported case, was associated with an excellent prognosis, supporting the idea that these patients should not be overtreated.<\/jats:p>","DOI":"10.1111\/cup.12720","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T10:48:52Z","timestamp":1460717332000},"page":"702-706","source":"Crossref","is-referenced-by-count":22,"title":["Lymph node location of a clear cell hidradenoma: report of a patient and review of literature"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0869-8883","authenticated-orcid":false,"given":"Claire","family":"Tingaud","sequence":"first","affiliation":[{"name":"Service d'Anatomie et Cytologie Pathologiques CHU de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Costes","sequence":"additional","affiliation":[{"name":"Service d'Anatomie et Cytologie Pathologiques CHU de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Frouin","sequence":"additional","affiliation":[{"name":"Service d'Anatomie et de Cytologie Pathologiques CHU de Poitiers  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Delfour","sequence":"additional","affiliation":[{"name":"Service d'Anatomie et Cytologie Pathologiques CHU de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cribier","sequence":"additional","affiliation":[{"name":"Service de Dermatologie CHU de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Guillot","sequence":"additional","affiliation":[{"name":"Service de Dermatologie CHU de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Szablewski","sequence":"additional","affiliation":[{"name":"Service d'Anatomie et Cytologie Pathologiques CHU de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1087","volume-title":"Lever's histopathology of the skin","author":"Elder DE","year":"2014"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20168"},{"key":"e_1_2_5_4_1","volume-title":"McKee's pathology of the skin: with clinical correlations","author":"Calonje E","year":"2011"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.5858\/2005-129-e113-CCHAMO","article-title":"Clear cell hidradenoma: a mimic of metastatic clear cell tumors","volume":"129","author":"Volmar KE","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70002-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880160509"},{"key":"e_1_2_5_8_1","first-page":"2217","article-title":"Malignant hidradenoma: a report of two cases and review of the literature","volume":"26","author":"Liapakis IE","year":"2006","journal-title":"Anticancer Res"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198708000-00027"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5858\/134.5.781"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.18"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181984f10"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0b013e31804bdee1"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182699363"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200202000-00001"},{"key":"e_1_2_5_16_1","first-page":"193","article-title":"Metastatic benign pleomorphic adenoma. Report of a case and review of the literature","volume":"13","author":"Fern\u00e1ndez JR","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2005.00190.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(05)79849-5"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12329"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094399"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.02.028"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2007.10.007"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319176111"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20440"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896910382544"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20647"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2007.07.005"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.07.035"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2213-2"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01722.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.02.005"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12539"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12720","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T16:27:19Z","timestamp":1695745639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,17]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/cup.12720"],"URL":"https:\/\/doi.org\/10.1111\/cup.12720","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,17]]}}}