{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:22:23Z","timestamp":1778498543953,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Mammary\u2010like glands are normal appendages of anogenital skin and can give rise to epithelial and stromal tumors that closely resemble breast tumors. Cowden syndrome is an autosomal\u2010dominant cancer\u2010predisposition syndrome that is associated with increased risk of various benign and malignant tumors including breast cancers. Here, we report the first case of a proliferative lesion of mammary\u2010like glands in the setting of Cowden syndrome. A 27\u2010year\u2010old female with Cowden syndrome (<jats:styled-content style=\"fixed-case\">R130Q\u2010PTEN<\/jats:styled-content> mutation) presented with a 1\u2010cm tender, polypoid perianal lesion. An excisional biopsy revealed a circumscribed, lobulated lesion with fibromyxoid stroma and epithelial hyperplasia with apocrine and columnar cell changes that was arranged in papillary, micropapillary and focal cribriform architecture. The features strikingly resembled proliferative changes commonly seen in the breast. Interestingly, the patient subsequently developed an atypical complex sclerosing lesion of the breast. Given the increased risk of breast neoplasia in Cowden syndrome, and the morphologic relationship between breast glands and mammary\u2010like glands, this case raises the possibility of an increased risk of neoplasia arising in mammary\u2010like glands in the setting of Cowden syndrome.<\/jats:p>","DOI":"10.1111\/cup.12721","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T07:49:15Z","timestamp":1461052155000},"page":"707-710","source":"Crossref","is-referenced-by-count":9,"title":["Proliferative lesion of anogenital mammary\u2010like glands in the setting of Cowden syndrome: case report and review of the literature"],"prefix":"10.1111","volume":"43","author":[{"given":"Amin A.","family":"Hedayat","sequence":"first","affiliation":[{"name":"Department of Pathology Dartmouth\u2010Hitchcock Medical Center and Geisel School of Medicine at Dartmouth  Lebanon NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason R.","family":"Pettus","sequence":"additional","affiliation":[{"name":"Department of Pathology Dartmouth\u2010Hitchcock Medical Center and Geisel School of Medicine at Dartmouth  Lebanon NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Marotti","sequence":"additional","affiliation":[{"name":"Department of Pathology Dartmouth\u2010Hitchcock Medical Center and Geisel School of Medicine at Dartmouth  Lebanon NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura J.","family":"Tafe","sequence":"additional","affiliation":[{"name":"Department of Pathology Dartmouth\u2010Hitchcock Medical Center and Geisel School of Medicine at Dartmouth  Lebanon NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan D.","family":"Holubar","sequence":"additional","affiliation":[{"name":"Section of Oncologic Surgery Dartmouth\u2010Hitchcock Medical Center and Geisel School of Medicine at Dartmouth  Lebanon NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Lisovsky","sequence":"additional","affiliation":[{"name":"Department of Pathology Dartmouth\u2010Hitchcock Medical Center and Geisel School of Medicine at Dartmouth  Lebanon NH 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