{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:08:12Z","timestamp":1759813692926},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Background<\/jats:title>Distinguishing types of lymphocytic scarring alopecia is often difficult because of the overlapping features. Recently, the presence of plasmacytoid dendritic cells (PDCs<\/jats:styled-content>) in cutaneous lupus erythematosus (LE<\/jats:styled-content>) was demonstrated and further shown to help distinguish lupus from other dermatoses.1\u20106 This study aims to determine if the presence and distribution of PDCs<\/jats:styled-content> can aid in the diagnosis of scarring alopecia.<\/jats:p><\/jats:sec>Methods<\/jats:title>Cases of scarring alopecia due to chronic cutaneous lupus erythematosus (CCLE<\/jats:styled-content>), lichen planopilaris (LPP<\/jats:styled-content>) and central centrifugal cicatricial alopecia (CCCA<\/jats:styled-content>) were examined histopathologically. A total of 45 total biopsies were evaluated and CD123<\/jats:styled-content> immunohistochemistry was performed on all samples. The relative percentage of PDCs<\/jats:styled-content>, the presence of clusters and the distribution of CD123<\/jats:styled-content>+ cells were noted.<\/jats:p><\/jats:sec>Results<\/jats:title>PDCs<\/jats:styled-content> comprised a greater percentage of the infiltrate and were arranged in clusters in cases of CCLE<\/jats:styled-content> vs. LPP<\/jats:styled-content> or CCCA<\/jats:styled-content>. In CCLE<\/jats:styled-content>, the location of PDCs<\/jats:styled-content> was perivascular, perifollicular, perieccrine and\/or at the follicular junction. In LPP<\/jats:styled-content> and CCCA<\/jats:styled-content>, PDCs<\/jats:styled-content> were mainly arranged as single, interstitial cells.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our findings suggest that the presence and arrangement of CD123<\/jats:styled-content>+ PDCs<\/jats:styled-content> may assist in the diagnosis of scarring alopecia. We anticipate this will be of value in diagnosing challenging cases of highly inflammatory scarring alopecia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12725","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T11:29:19Z","timestamp":1462102159000},"page":"643-648","source":"Crossref","is-referenced-by-count":22,"title":["CD123<\/scp> immunohistochemistry for plasmacytoid dendritic cells is useful in the diagnosis of scarring alopecia"],"prefix":"10.1111","volume":"43","author":[{"given":"Katherine","family":"Fening","sequence":"first","affiliation":[{"name":"Division of Dermatopathology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viswas","family":"Parekh","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristopher","family":"McKay","sequence":"additional","affiliation":[{"name":"Division of Dermatopathology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12416"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01587.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.892"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00848.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01779.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12105"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2009.06.013"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-117531"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.09.014"},{"key":"e_1_2_5_11_1","article-title":"Plasmacytoid dendritic cells in alopecia areata: missing link?","author":"Abou Rahal J","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80091-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38301"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12725","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T16:26:48Z","timestamp":1695745608000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,3]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/cup.12725"],"URL":"https:\/\/doi.org\/10.1111\/cup.12725","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,3]]}}}