{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T20:25:22Z","timestamp":1745180722622},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>We describe a 65\u2010year\u2010old Caucasian female with well\u2010controlled Hailey\u2013Hailey disease (HHD) who developed acute generalized exanthematous pustulosis (AGEP) with severe systemic symptoms. Despite sparing of the patient's intertriginous skin, histopathologic evidence of HHD was observed in all biopsies, suggestive of a unique koebernization phenomenon of HHD to areas of cutaneous drug eruption. While internal organ involvement is less commonly reported in AGEP, there are an increasing number of patients with signs and symptoms suggestive of an AGEP\/drug reaction with eosinophilia and systemic symptoms (DRESS) spectrum of cutaneous drug disorders. Early diagnosis of patients with AGEP and systemic symptoms is critical so that these patients may receive prompt and aggressive systemic therapy to decrease the risk of end organ damage and improve overall morbidity and mortality.<\/jats:p>","DOI":"10.1111\/cup.12771","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T15:26:54Z","timestamp":1468942014000},"page":"1031-1035","source":"Crossref","is-referenced-by-count":8,"title":["Koebnerization of Hailey\u2013Hailey disease into a cutaneous drug eruption of acute generalized exanthematous pustulosis associated with systemic symptoms"],"prefix":"10.1111","volume":"43","author":[{"given":"Mariam B.","family":"Totonchy","sequence":"first","affiliation":[{"name":"Department of Dermatology Yale School of Medicine  New Haven CT 06520\u20108059 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"McNiff","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale School of Medicine  New Haven CT 06520\u20108059 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Bunick","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale School of Medicine  New Haven CT 06520\u20108059 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028003113.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680080069004"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12502"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1152"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12501"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00658.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.7.1131"},{"key":"e_1_2_4_9_1","first-page":"251","article-title":"Acute generalized erythematous pustulosis occurring with Hailey\u2010Hailey disease","volume":"10","author":"Deng A","year":"2012","journal-title":"Skinmed"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12685"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-72"},{"key":"e_1_2_4_12_1","first-page":"359","article-title":"Denominations and classification of severe cutaneous adverse reactions to drugs: splitters versus mergers","volume":"17","author":"Valeyrie\u2010Allanore L","year":"2007","journal-title":"Eur J Dermatol"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450601.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450502.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12125"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12528.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.9.5.1149"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03415.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12771","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:14:28Z","timestamp":1696367668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,22]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/cup.12771"],"URL":"https:\/\/doi.org\/10.1111\/cup.12771","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,22]]}}}