{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:48:11Z","timestamp":1792504091095,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Skin is commonly affected by extraintestinal manifestations of inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>), but a controlled, systematic histopathologic analysis of cutaneous lesions is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 4147 classified <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> [Crohn disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) or ulcerative colitis (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>); 2000\u20132013] resections were cross referenced with skin biopsies. Associated non\u2010neoplastic skin biopsies were categorized by basic reaction pattern and neutrophilic vs. granulomatous.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 4147 patients, 133 had non\u2010neoplastic skin biopsies (106\/2772, 3.7% <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>; 27\/1375, 2% <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>). Overall, miscellaneous &gt; nodular and diffuse dermal &gt; spongiotic dermatitides were most common (31.6, 21.8 and 15%, respectively). Spongiotic dermatitis, vasculitis, panniculitis and infections showed <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> bias. Psoriasiform, perivascular, nodular\/diffuse dermal and bullous categories, as well as neutrophilic processes, showed <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> bias. Leukocytoclastic vasculitis, panniculitis and pyoderma gangrenosum were exclusive to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and psoriasis vulgaris to <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>. One <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> patient had inverse psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings show the majority of dermatopathologic manifestations of <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> to have overlapping histology or pathophysiology to intestinal disease; with a wider spectrum of histologic patterns than typically discussed. Diseases \u2018classically\u2019 associated with <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> are relatively rare biopsy specimens. Cutaneous manifestations of <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> are more common in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> and should be considered when reviewing an unexplained skin lesion in an <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12777","type":"journal-article","created":{"date-parts":[[2016,8,6]],"date-time":"2016-08-06T09:01:40Z","timestamp":1470474100000},"page":"946-955","source":"Crossref","is-referenced-by-count":18,"title":["Cutaneous manifestations in inflammatory bowel disease: a single institutional study of non\u2010neoplastic biopsies over 13 years"],"prefix":"10.1111","volume":"43","author":[{"given":"Jennifer S.","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Pathology Cleveland Clinic Foundation  Cleveland OH 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