{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:30:21Z","timestamp":1761823821517},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glatiramer acetate, given as a 40 mg subcutaneous injection thrice weekly, was recently approved by the <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content> based on data suggesting better compliance and a more favorable side effect profile compared to lower dose, daily dosing. The most commonly reported adverse events are transient injection site reactions involving redness and pain at the site; however, more pronounced panniculitis and lipoatrophy have also been reported. Here, we present the case of a 51\u2010year\u2010old female treated with higher dose glatiramer acetate who presented with a cutaneous injection site reaction consistent with Nicolau syndrome. The excised specimen revealed typical glatiramer acetate\u2010associated panniculitis, alongside subcutaneous sclerosis. This case shows the spectrum of cutaneous complications possible with glatiramer acetate injections, the finding of sclerosis being relatively infrequently reported. Given the relatively short duration of trials leading to <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content> approval of thrice weekly dosing of glatiramer acetate, clinicians should perform careful clinical and histopathological evaluation and reporting of patients who experience injection site reactions.<\/jats:p>","DOI":"10.1111\/cup.12791","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T08:17:09Z","timestamp":1470989829000},"page":"1056-1061","source":"Crossref","is-referenced-by-count":10,"title":["Nicolau syndrome and localized panniculitis: a report of dual diagnoses with an emphasis on morphea profunda\u2010like changes following injection with glatiramer acetate"],"prefix":"10.1111","volume":"43","author":[{"given":"Sarah E.","family":"Mott","sequence":"first","affiliation":[{"name":"School of Medicine Creighton University  Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary 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