{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:44:35Z","timestamp":1788799475319,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alemtuzumab is a humanized monoclonal antibody directed against <jats:styled-content style=\"fixed-case\">CD52<\/jats:styled-content>, a cell surface antigen on B and T lymphocytes, and used to treat B\u2010cell chronic lymphocytic leukemia and cutaneous T\u2010cell lymphoma. Skin rash is a common adverse reaction following treatment with alemtuzumab. However, the clinicopathologic features and immunologic basis for the reaction have not been previously reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our hospital's electronic pathology database was searched for cases with documentation of \u2018alemtuzumab\u2019 or \u2018anti\u2010<jats:styled-content style=\"fixed-case\">CD52<\/jats:styled-content>\u2019 in the clinical history provided by either the ordering physician or the pathologist. Clinical and histopathologic review of the cases was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients with cutaneous T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>) or chronic lymphocytic leukemia (<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>) were treated with alemtuzumab, and developed pruritic, erythematous papules and plaques. Histopathology of the skin lesions revealed subacute spongiotic dermatitis with multifocal parakeratosis, endothelial activation and perivascular lymphocytic infiltrate. Eosinophils were not a prominent feature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We describe the clinicopathologic features of a novel hypersensitivity reaction to alemtuzumb, and hypothesize it may be due to an immunologic response precipitated by the persistence of resident memory T\u2010cells (<jats:styled-content style=\"fixed-case\">T<jats:sub>RM<\/jats:sub><\/jats:styled-content>) in the skin. Our findings raise awareness for a novel reaction pattern and guide the histopathologic interpretation of lesions which may clinically mimic residual or recurrent cutaneous lymphoproliferative disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12800","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T05:56:43Z","timestamp":1471413403000},"page":"989-993","source":"Crossref","is-referenced-by-count":10,"title":["Histopathologic spectrum of hypersensitivity reactions associated with anti\u2010<scp>CD52<\/scp> therapy (alemtuzumab)"],"prefix":"10.1111","volume":"43","author":[{"given":"Stacie L.","family":"Clark","sequence":"first","affiliation":[{"name":"Program in Dermatopathology, Department of Pathology Brigham and Women's Hospital, Harvard Medical School  Boston MA USA"},{"name":"College of Human Medicine Michigan State University  Grand Rapids MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie Y.","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Pathology Tufts Medical Center, Tufts School of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Dana Farber Cancer Institute Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole R.","family":"LeBeouf","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Program in Dermatopathology, Department of Pathology Brigham and Women's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Kupper","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael A.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine G.","family":"Lian","sequence":"additional","affiliation":[{"name":"Program in Dermatopathology, Department of Pathology Brigham and Women's Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1385\/MO:19:2S:S27"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3389"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07606.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0159"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.01.027"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700277"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.247"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12800","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:14:17Z","timestamp":1696367657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,9]]},"references-count":8,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/cup.12800"],"URL":"https:\/\/doi.org\/10.1111\/cup.12800","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,9]]}}}