{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:55:55Z","timestamp":1782478555061,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Background<\/jats:title>Hydroa vacciniforme (HV<\/jats:styled-content>) is associated with Epstein\u2010Barr virus (EBV<\/jats:styled-content>) infection and a risk of transformation to lymphoma.<\/jats:p><\/jats:sec>Methods<\/jats:title>We retrospectively analyzed six HV<\/jats:styled-content> cases for EBV<\/jats:styled-content> association and transformation to HV<\/jats:styled-content>\u2010like T\u2010cell lymphoma. Clinicopathologic features were reviewed and cases were assessed for EBV<\/jats:styled-content>\u2010encoded RNA<\/jats:styled-content> (EBER<\/jats:styled-content>) by in situ<\/jats:italic> hybridization, double staining with immunohistochemistry and EBER<\/jats:styled-content> and for T\u2010cell clonality.<\/jats:p><\/jats:sec>Results<\/jats:title>The male\u2010to\u2010female ratio was 5:1, with a median age at diagnosis of 18.5 years. All patients initially had recurrent vesicles, necrotic ulcers or scars on sun\u2010exposed areas. Symptoms were present before diagnosis between 2 weeks to 10 years. The mean follow\u2010up time was 106.3 months. Four patients (67%) were EBV<\/jats:styled-content>\u2010positive. All four EBV<\/jats:styled-content>\u2010positive and one EBV<\/jats:styled-content>\u2010negative patients had relapsing clinical course. Double staining proved EBV<\/jats:styled-content> infection in T\u2010cells. Moreover, one EBV<\/jats:styled-content>\u2010positive patient developed HV<\/jats:styled-content>\u2010like T\u2010cell lymphoma with hemophagocytosis after 209 months of recurrent papulovesicular eruptions and eventually died. T\u2010cell clonality was successfully performed in four HV<\/jats:styled-content> patients and all showed polyclonal results; the transformed HV<\/jats:styled-content>\u2010like T\u2010cell lymphoma was monoclonal.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In EBV<\/jats:styled-content> endemic areas, HV<\/jats:styled-content> is frequently (67%) associated with EBV<\/jats:styled-content> infection, but transformation to HV<\/jats:styled-content>\u2010like T\u2010cell lymphoma seems to be uncommon (17%) and bear a dismal outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12801","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T06:12:40Z","timestamp":1471414360000},"page":"1102-1111","source":"Crossref","is-referenced-by-count":20,"title":["Hydroa vacciniforme and hydroa vacciniforme\u2010like T\u2010cell lymphoma: an uncommon event for transformation"],"prefix":"10.1111","volume":"43","author":[{"given":"Chien\u2010Chin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology Chia\u2010Yi Christian Hospital Chia\u2010Yi Taiwan"},{"name":"Department of Cosmetic Science Chia Nan University of Pharmacy and Science Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kung\u2010Chao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine National Cheng Kung University and Hospital Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Yu\u2010Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine National Cheng Kung University and Hospital Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,9]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"132","article-title":"Lecons theoriques et cliniques sur les affectations generiques de la peau","volume":"1","author":"Bazin E","year":"1862","journal-title":"Delabrage"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90127-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1982.01650200056017"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1986.01660230102021"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02777.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.5.587"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0596-551"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(02)00112-9"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.3.744.bloodjournal853744"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800369"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1882"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1027-8117(10)60037-7"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.861068"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428191003660631"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp064"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7216-0040-6.00029-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-502203"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06038.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129039-200203000-00002"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181fbb4fd"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa9122"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90181-7"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13411"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.99812.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02213.x"},{"key":"e_1_2_5_27_1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12322"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12801","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T19:34:10Z","timestamp":1695756850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,9]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/cup.12801"],"URL":"https:\/\/doi.org\/10.1111\/cup.12801","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,9]]}}}