{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:25:35Z","timestamp":1787793935529,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Primary cutaneous <jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content>+ small\u2010\/medium\u2010sized pleomorphic T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content>+ <jats:styled-content style=\"fixed-case\">PCSM\u2010TCL<\/jats:styled-content>) is a rare lymphoproliferative disorder with a favorable prognosis. Distinguishing it from other cutaneous lymphomas is often a challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively collected <jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">PCSM\u2010TCL<\/jats:styled-content> cases from two centers (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> Anderson Cancer Center, <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content> and University of Milan, Italy) and evaluated their clinicopathological features. Array\u2010comparative genomic hybridization (<jats:styled-content style=\"fixed-case\">aCGH<\/jats:styled-content>) analysis was performed on 11 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 62 patients were identified. Single lesions were the most common clinical presentations (79%). Five patients (8%) showed multiple <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>\u2010like plaques. All patients' disease had an indolent course. The infiltrate was nodular and diffuse, multinodular or superficial but in all cases, it was characterized by small\/medium pleomorphic <jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content>+\/<jats:styled-content style=\"fixed-case\">CD279<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">PD1<\/jats:styled-content>+) lymphocytes grouped in clusters and \u2018pseudorosettes\u2019 around B\u2010cells. <jats:styled-content style=\"fixed-case\">aCGH<\/jats:styled-content> analysis showed no significant genomic abnormalities. Single lesions were mainly treated with surgical excision (91%) and\/or radiotherapy (95%) with low rate of relapse (12%). For multiple lesions, topical steroids, nitrogen mustard and phototherapy were mainly used but the rate of relapse was high (69%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">PCSM\u2010TCL<\/jats:styled-content> is characterized by heterogeneous clinical presentations. The arrangement of atypical cells in clusters or pseudorosettes is a useful criterion for diagnosis. The absence of significant genomic alterations is in agreement with its indolent behavior.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12806","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T08:16:37Z","timestamp":1471940197000},"page":"1121-1130","source":"Crossref","is-referenced-by-count":56,"title":["Clinicopathological and molecular study of primary cutaneous CD4+ small\/medium\u2010sized pleomorphic T\u2010cell lymphoma"],"prefix":"10.1111","volume":"43","author":[{"given":"Silvia","family":"Alberti\u2010Violetti","sequence":"first","affiliation":[{"name":"UOC Dermatologia Fondazione IRCCS Ca' Granda \u2013 Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A","family":"Torres\u2010Cabala","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology Section University of Texas, MD Anderson Cancer Center  Houston TX USA"},{"name":"Department of Dermatology University of Texas, MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhshandra","family":"Talpur","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Texas, MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Corti","sequence":"additional","affiliation":[{"name":"UOC Dermatologia Fondazione IRCCS Ca' Granda \u2013 Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Fanoni","sequence":"additional","affiliation":[{"name":"UOC Dermatologia Fondazione IRCCS Ca' Granda \u2013 Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigia","family":"Venegoni","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisiopatologia Medico\u2010Chirurgica e dei Trapianti Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Berti","sequence":"additional","affiliation":[{"name":"UOC Dermatologia Fondazione IRCCS Ca' Granda \u2013 Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Dipartimento di Scienze della Salute Universit\u00e0 degli Studi di Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Duvic","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Texas, MD Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_5_3_1","first-page":"304","volume-title":"WHO classification of tumors of haematopoietic and lymphoid tissues","author":"Gaulard 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