{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T19:05:43Z","timestamp":1748631943158},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T00:00:00Z","timestamp":1474934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Melanocytoma are the melanocytic tumors originating from leptomeningeal melanocytes. Melanocytomas are commonly seen in the central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) and are often associated with neurocutaneous melanosis (<jats:styled-content style=\"fixed-case\">NCM<\/jats:styled-content>). However, simultaneous presentation of intra\u2010axial and extracranial melanocytoma is a very rare event. Here, we report a unique case of 21\u2010year\u2010old male with intermediate\u2010grade subcutaneous (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) melanocytoma, mimicking lipoma, occurred synchronously with an intracranial melanocytoma, not associated with <jats:styled-content style=\"fixed-case\">NCM<\/jats:styled-content>. A 21\u2010year\u2010old Caucasian male presented to the emergency department (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) with severe vertigo and vomiting. A magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) of the brain was performed at the <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>, which revealed an <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> mass in the right occipital scalp and a right cerebellopontine angle (<jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content>) mass. Excision of the <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> mass revealed a well\u2010circumscribed highly pigmented melanocytic tumor. The <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> mass tumor cells were positive for melanocytic lineage markers. The histopathological features were between benign melanocytomas and malignant melanomas. The Ki67 and <jats:styled-content style=\"fixed-case\">PHH3 IHCs<\/jats:styled-content> confirm the intermediate grade of the tumors. An array\u2010<jats:styled-content style=\"fixed-case\">CGH<\/jats:styled-content> (comparative genome hybridization) and next\u2010generation sequencing analysis of the tumor <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> extracted from the formalin\u2010fixed paraffin\u2010embedded tissue reveals chromosome 6p gain and p.<jats:styled-content style=\"fixed-case\">Q209P<\/jats:styled-content> mutation in the <jats:italic><jats:styled-content style=\"fixed-case\">GNAQ<\/jats:styled-content><\/jats:italic> gene, respectively, consistent with the diagnosis of intermediate\u2010grade melanocytoma.<\/jats:p>","DOI":"10.1111\/cup.12808","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T09:48:04Z","timestamp":1472550484000},"page":"1186-1196","source":"Crossref","is-referenced-by-count":4,"title":["Subcutaneous melanocytoma mimicking a lipoma: a rare presentation of a rare neoplasm with histological, immunohistochemical, cytogenetic and molecular characterization"],"prefix":"10.1111","volume":"43","author":[{"given":"Nitin","family":"Marwaha","sequence":"first","affiliation":[{"name":"Department of Pathology Saint Louis University School of Medicine  St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline R.","family":"Batanian","sequence":"additional","affiliation":[{"name":"Department of Pathology Saint Louis University School of Medicine  St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen R.","family":"Coppens","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Saint Louis University School of Medicine  St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Pierson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Saint Louis University School of Medicine  St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Richards\u2010Yutz","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Pennsylvania School of Medicine  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Ebrahimzadeh","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Pennsylvania School of Medicine  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arupa","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Pennsylvania School of Medicine  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Guzman","sequence":"additional","affiliation":[{"name":"Department of Pathology Saint Louis University School of Medicine  St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199907000-00001"},{"key":"e_1_2_5_3_1","volume-title":"World Health Organization histological classification of tumours of the central nervous system","author":"Louis DN","year":"2016"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104658"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01406621"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-10-135"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/1793-5482.131068"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.149438"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000568"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194472"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2010.01.017"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071550"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266082"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/340692a0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-014-9841-3"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0611-3"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-0948-x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2012.01288.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.34.0695"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3171\/spi.2007.6.5.451"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2016.03.007"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2015.09.036"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-013-2773-x"},{"key":"e_1_2_5_24_1","first-page":"534","article-title":"Multiple spinal cord melanoma: case report with emphasis on the difficult preoperative diagnosis","volume":"23","author":"Huang X","year":"2013","journal-title":"Turk Neurosurg"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.cr2012-0241"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.5137\/1019-5149.jtn.4322-11.1"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-011-1143-x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/30756805"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.3.JNS081096"},{"key":"e_1_2_5_30_1","first-page":"542","article-title":"Meningeal melanocytoma. An uncommon diagnostic pitfall in surgical neuropathology","volume":"119","author":"O'Brien TF","year":"1995","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511897948"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.2.381"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.3.0619"},{"key":"e_1_2_5_34_1","first-page":"561","article-title":"A new variety of neurocutaneous melanosis: benign leptomeningeal melanocytoma associated with extensive Mongolian spot on the back","volume":"99","author":"Kawara S","year":"1989","journal-title":"Nihon Hifuka Gakkai Zasshi"},{"key":"e_1_2_5_35_1","first-page":"287","article-title":"Migration of melanocytic lineage\u2010derived cells","volume":"29","author":"Domingues MJ","year":"2013","journal-title":"Med Sci"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000584"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-06982-6.00016-X"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07586"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1063"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930201)71:3<811::AID-CNCR2820710325>3.0.CO;2-F"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1750"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182a0a150"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12228"},{"key":"e_1_2_5_44_1","first-page":"2170","article-title":"Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization","volume":"58","author":"Bastian BC","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0749-z"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.02.030"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.04.015"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.4161\/23723548.2014.970957"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12808","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T19:34:25Z","timestamp":1695756865000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,27]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/cup.12808"],"URL":"https:\/\/doi.org\/10.1111\/cup.12808","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,27]]}}}