{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:10:01Z","timestamp":1773245401518,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Plasma cell proliferations in specific cutaneous lesions of angioimmunoblastic T\u2010cell lymphoma(<jats:styled-content style=\"fixed-case\">AITL<\/jats:styled-content>) are very uncommon. Here, we report a case of clonal plasma cell proliferation in skin with heavy\u2010chain\u2010immunoglobulin\u2010isotype\u2010switch after cutaneous disease progression. Histopathologically, initial plaque lesions were suggestive of marginal\u2010zone B\u2010cell\u2010lymphoma. Nevertheless, this 77\u2010year\u2010old lady was diagnosed with <jats:styled-content style=\"fixed-case\">AITL<\/jats:styled-content> after the progression of skin lesions from plaques to nodular tumors. A lymph node biopsy confirmed the diagnosis. Both cutaneous specimens showed a polymorphic cellular infiltrate with atypical T\u2010cell\u2010lymphocytes arranged in a pseudonodular pattern that expressed <jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">PD1<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BCL6<\/jats:styled-content>, with patchy expression of <jats:styled-content style=\"fixed-case\">CD30<\/jats:styled-content>. Interestingly, a slight <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>\u2010Lambda plasma cell component was seen at the periphery of the infiltrate in the first specimen which increased in number in the later nodular lesion, showing not only Lambda light chain restriction and <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content> but also <jats:styled-content style=\"fixed-case\">IgG4<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> studies for <jats:styled-content style=\"fixed-case\">IgH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> genes showed an <jats:styled-content style=\"fixed-case\">IgH<\/jats:styled-content> clonal peak on both skin lesions but not on lymph node biopsy. On the contrary, the same clonal <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> peak was found in the three specimens. Neoplastic follicular helper T\u2010cells within cutaneous\u2010specific microenvironment could be responsible for the modulation of the immunoglobulin isotype class switch change. Further studies are needed to support this hypothesis.<\/jats:p>","DOI":"10.1111\/cup.12814","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T07:23:38Z","timestamp":1473146618000},"page":"1203-1210","source":"Crossref","is-referenced-by-count":9,"title":["Angioimmunoblastic T\u2010cell lymphoma with a clonal plasma cell proliferation that underwent immunoglobulin isotype switch in the skin, coinciding with cutaneous disease progression"],"prefix":"10.1111","volume":"43","author":[{"given":"Ana E.","family":"Su\u00e1rez","sequence":"first","affiliation":[{"name":"Pathology Department Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Artiga","sequence":"additional","affiliation":[{"name":"Tumor Bank Centro Nacional de Investigaciones Oncol\u00f3gicas  Madrid 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