{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:21:10Z","timestamp":1778498470108,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Cowden syndrome (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) is an uncommon autosomal dominant multiorgan\/system genodermatosis. It is characterized by the development of multiple hamartomas of endodermal, mesodermal and ectodermal origin, an increased lifetime risk of breast, thyroid, endometrial and other cancers and an identifiable germline mutation. Mucocutaneous hamartomas are the most common lesions seen and mainly include facial trichilemmomas, oral mucosal papillomas and benign acral keratoses. Herein, we report a case of a 63\u2010year\u2010old Caucasian male with a long\u2010established diagnosis of <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> and history of thyroid cancer, colonic polyps, and innumerable trichilemmomas, seborrheic keratoses, squamous papillomas and non\u2010melanoma skin cancers excised in the past. He presented in four separate occasions with small skin\u2010colored papulonodular lesions that upon excision revealed to be clear cell acanthomas. He also developed a tumor in the preauricular area that was completely resected and was found to be a sebaceous lymphadenoma (SLA) of the parotid gland. This is to our knowledge, the second report of clear cell acanthoma and also the second reported case of SLA in a patient with <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cup.12823","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T13:47:20Z","timestamp":1475070440000},"page":"79-82","source":"Crossref","is-referenced-by-count":13,"title":["Multiple clear cell acanthomas and a sebaceous lymphadenoma presenting in a patient with Cowden syndrome\u00a0\u2013\u00a0a case report"],"prefix":"10.1111","volume":"44","author":[{"given":"Silvia","family":"Potenziani","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Applebaum","sequence":"additional","affiliation":[{"name":"Department of Dermatology Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhuvaneswari","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston TX USA"},{"name":"Department of Pathology Michael E. DeBakey VA Medical Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Hafeez","family":"Diwan","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston TX USA"},{"name":"Department of Dermatology Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.156360"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2015.27.3.306"},{"key":"e_1_2_3_4_1","first-page":"109","article-title":"Targeted therapy for genetic cancer syndromes: Von Hippel\u2010Lindau disease, Cowden syndrome, and Proteus syndrome","volume":"19","author":"Agarwal R","year":"2015","journal-title":"Discov Med"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-008-9187-7"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2012.01888.x"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.030569"},{"issue":"3","key":"e_1_2_3_8_1","first-page":"1171","article-title":"A rare case of multiple clear cell acanthoma with a relatively rapid development of the lower legs","volume":"55","author":"Rotaru M","year":"2014","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12206"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.06.039"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.141815"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.135"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.06.026"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12827"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2009.00846.x"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31824a22f9"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12823","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:36:39Z","timestamp":1696336599000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,20]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/cup.12823"],"URL":"https:\/\/doi.org\/10.1111\/cup.12823","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,20]]}}}