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We report a case of a patient presenting with blackened skin overlying veins recently treated with endovenous laser and foam sclerotherapy. The patient was a 44\u2010year\u2010old male with systemic sclerosis who commenced minocycline for the treatment of rosacea 5 months prior. Histological examination of the discolored tissue and underlying vein revealed hemosiderin deposition in the dermis and pigmented macrophages within the sub\u2010endothelial layer of the vein wall with a staining pattern consistent with<jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>. Venous tissue has not previously been reported in the literature as a target of minocycline pigmentation. Our patient preferred to control his rosacea by continuing to take minocycline. Follow\u2010up ultrasound examinations revealed the treated vessels to be fully occluded with no evidence of recanalization, residual flow or ongoing thrombophlebitis. Despite a good sclerotherapy outcome, the pigmentation did not subside over 2 years. This case demonstrates that oral minocycline may induce significant and potentially long\u2010term pigmentation in predisposed patients undergoing sclerotherapy.<\/jats:p>","DOI":"10.1111\/cup.12824","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T13:53:09Z","timestamp":1475070789000},"page":"83-92","source":"Crossref","is-referenced-by-count":7,"title":["Black veins: a case of minocycline\u2010induced pigmentation post\u2010sclerotherapy and a review of literature"],"prefix":"10.1111","volume":"44","author":[{"given":"Phoebe","family":"Star","sequence":"first","affiliation":[{"name":"Dermatology, Phlebology and Fluid Mechanics Research Laboratory St Vincent's Centre for Applied Medical Research Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Choy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Skin and Cancer Foundation Australia Darlinghurst 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