{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:59:21Z","timestamp":1782493161828,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Trichilemmomas are benign cutaneous proliferations derived from the outer root sheath of the hair follicle. They most often occur on the head and neck region and show a female predominance. When multiple, they are associated with Cowden syndrome (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>), a rare disorder due to an autosomal dominant germline mutation in <jats:italic>PTEN<\/jats:italic> (phosphatase and tensin homolog on chromosome 10), a tumor suppressor gene. Trichilemmomas outside of the head and neck region are rare, and as such, the association with <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> is not clear. A 28\u2010year\u2010old healthy female with no significant family history of cancer presented to her dermatologist with multiple erythematous papules on the left anterior ankle, starting at birth. A shave biopsy confirmed the diagnosis of trichilemmoma with focal desmoplastic features (or desmoplastic trichilemmoma). A <jats:italic>PTEN<\/jats:italic> immunohistochemical study showed patchy (but not complete) loss of staining of the lesional cells. After shave removal, the trichilemmomas recurred 1\u20132 months later.<\/jats:p>","DOI":"10.1111\/cup.12825","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T13:53:13Z","timestamp":1475070793000},"page":"93-97","source":"Crossref","is-referenced-by-count":5,"title":["Linear trichilemmomas on the ankle of a 28\u2010year\u2010old female"],"prefix":"10.1111","volume":"44","author":[{"given":"Jessica L.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Department of Dermatology Tufts Medical Center  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Plotnikova","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tufts Medical Center  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Seymour","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology Miraca Life Sciences  Newton MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciaran M.","family":"Mannion","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hackensack University Medical Center  Hackensack NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Danialan","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology Miraca Life Sciences  Newton MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rosmarin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tufts Medical Center  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1962.01590100044012"},{"key":"e_1_2_5_3_1","first-page":"104","article-title":"Trichilemmoma","volume":"96","author":"Maher EE","year":"2015","journal-title":"Cutis"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071782"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199702)51:2<119::AID-JMV6>3.0.CO;2-A"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02163.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31817903f5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt277"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.11.828"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2012.01888.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-58-1-136"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31824a22f9"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2283"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31827e28f7"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02514.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199204000-00004"},{"key":"e_1_2_5_17_1","first-page":"35","article-title":"Cowden disease. 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