{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:00:04Z","timestamp":1773910804297,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Angiosarcoma is a malignancy of vascular endothelial cells which may arise secondarily as a complication of lymphedema, including chronic lymphedema of morbid obesity. Amplifications in <jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content> are frequently present in secondary angiosarcoma (arising in irradiated sites and chronic lymphedema) and less frequently in primary cutaneous angiosarcoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the presence of <jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content> amplifications in two cases of cutaneous angiosarcoma secondary to chronic lymphedema of morbid obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is a case series of two patients with cutaneous angiosarcoma. Clinical data was retrieved from the medical records. Histopathological analysis of the biopsy specimens was performed, including immunohistochemistry, along with fluorescence <jats:italic>in situ<\/jats:italic> hybridization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Angiosarcoma arose in the setting of massive chronic lymphedema complicating morbid obesity without other predisposing risk factors. Both cases exhibited epithelioid cell morphology and high\u2010level <jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content> amplification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report <jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content> amplification in two cases of angiosarcoma arising in massive chronic lymphedema of morbid obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12827","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T18:20:01Z","timestamp":1475259601000},"page":"15-19","source":"Crossref","is-referenced-by-count":11,"title":["<i><scp>MYC<\/scp><\/i> amplification in angiosarcomas arising in the setting of chronic lymphedema of morbid obesity"],"prefix":"10.1111","volume":"44","author":[{"given":"David","family":"Harker","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center  Dallas TX USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Jennings","sequence":"additional","affiliation":[{"name":"Paul L. Foster School of Medicine  El Paso TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"McDonough","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center  Dallas TX USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Mauskar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center  Dallas TX USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Savory","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center  Dallas TX USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Hosler","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center  Dallas TX USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-3838","authenticated-orcid":false,"given":"Travis","family":"Vandergriff","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center  Dallas TX USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01116.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70170-9"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.359"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.03.004"},{"key":"e_1_2_4_6_1","first-page":"931973","article-title":"Cutaneous epithelioid clear cells angiosarcoma in a young woman with congenital lymphedema","volume":"2013","author":"Tabareau\u2010Delalande F","year":"2013","journal-title":"Case Rep Pathol"},{"key":"e_1_2_4_7_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.5858\/2001-125-0531-CACMO","article-title":"Cutaneous angiosarcoma complicating morbid obesity","volume":"125","author":"Azam M","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01785.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01703.x"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090637"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.134"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01843.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.163"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1979.01370250084018"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61772-5"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12827","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12827","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:36:12Z","timestamp":1696336572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,21]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/cup.12827"],"URL":"https:\/\/doi.org\/10.1111\/cup.12827","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,21]]}}}