{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:11:45Z","timestamp":1791234705922,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Postinflammatory hyperpigmentation (<jats:styled-content style=\"fixed-case\">PIH<\/jats:styled-content>) commonly occurs, but the histopathological features are not well characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 21 <jats:styled-content style=\"fixed-case\">PIH<\/jats:styled-content> patients' medical charts were reviewed. Punch biopsies from lesional and perilesional normal skin were performed. Sections were stained with hematoxylin\u2010eosin, Fontana\u2010Masson, <jats:styled-content style=\"fixed-case\">NKI<\/jats:styled-content>\/beteb, microphthalmia\u2010associated transcription factor (<jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">CD68<\/jats:styled-content>, c\u2010kit, factor <jats:styled-content style=\"fixed-case\">XIIIa<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fontana\u2010Masson\u2010stained sections suggested two obvious <jats:styled-content style=\"fixed-case\">PIH<\/jats:styled-content> groups: epidermal (13 cases) and dermal (8 cases) pigmentation. The epidermal pigment group had increased epidermal basal pigmentation. The dermal pigment group had marked pigmentation within the upper dermis and decreased epidermal pigmentation. More intense perivascular lymphocytic infiltration was observed in the dermal pigment group. <jats:styled-content style=\"fixed-case\">NKI<\/jats:styled-content>\/beteb levels were increased in lesional skin in both groups. The numbers of <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>+ melanocytes were not different between lesional and perilesional normal skin in either group. The expression of <jats:styled-content style=\"fixed-case\">CD68<\/jats:styled-content> and c\u2010kit was significantly higher in the dermis of lesional skin than in normal skin in the dermal pigment group. <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 expression was upregulated in lesional skin in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PIH<\/jats:styled-content> patients can be classified into two histopathological groups: epidermal and dermal pigmentation. The dermal pigment group showed decreased levels of epidermal pigmentation. This study provides histopathological information that can improve the treatment of <jats:styled-content style=\"fixed-case\">PIH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12849","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T06:22:53Z","timestamp":1477030973000},"page":"118-124","source":"Crossref","is-referenced-by-count":58,"title":["Two histopathological patterns of postinflammatory hyperpigmentation: epidermal and dermal"],"prefix":"10.1111","volume":"44","author":[{"given":"Ji\u2010Youn","family":"Park","sequence":"first","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Hye","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Pathology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010So","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Chan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2012.684419"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2009.08077"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/11536930-000000000-00000"},{"key":"e_1_2_5_5_1","first-page":"20","article-title":"Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color","volume":"3","author":"Davis EC","year":"2010","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_5_6_1","volume-title":"Lever's histopathology of the skin","author":"Elder DE","year":"2009"},{"key":"e_1_2_5_7_1","volume-title":"Weedon's skin pathology","author":"Weedon D","year":"2010"},{"key":"e_1_2_5_8_1","volume-title":"McKee's pathology of the skin: with clinical correlations","author":"Calonje E","year":"2012"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-0963.2001.04556.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12021.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(97)00072-2"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01831.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12849","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12849","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:58:47Z","timestamp":1696334327000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/cup.12849"],"URL":"https:\/\/doi.org\/10.1111\/cup.12849","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}