{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T22:58:32Z","timestamp":1780786712774,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Folliculotropism in melanoma is poorly characterized and standard categorization for follicular involvement by melanoma is unavailable. We propose a logical categorization system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a search of our archives over a 24\u2010year period for cases mentioning the terms follicle, follicular, folliculotropic, folliculocentric and melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 90 cases of melanoma with involvement of the hair follicle. Distinct patterns were identified. The invasive patterns were primary follicular, folliculotropic and invasive arising from melanoma <jats:italic>in situ<\/jats:italic> (<jats:styled-content style=\"fixed-case\">MIS<\/jats:styled-content>) with extensive follicular involvement. Follicular involvement by <jats:styled-content style=\"fixed-case\">MIS<\/jats:styled-content> was either lentiginous, nested or a combination of both.<\/jats:p><jats:p>A total of 29 invasive melanomas were identified. Of these 12 had invasive melanoma around the hair follicle, 2 were primary follicular melanomas, 7 showed folliculotropism and 3 were invasive melanomas arising from <jats:styled-content style=\"fixed-case\">MIS<\/jats:styled-content> around the follicle. Seventeen invasive melanomas had follicles only involved by <jats:styled-content style=\"fixed-case\">MIS<\/jats:styled-content> (9 nested, 6 nested and lentiginous and 2 lentiginous).<\/jats:p><jats:p>A total of 61 cases of <jats:styled-content style=\"fixed-case\">MIS<\/jats:styled-content> with follicular involvement were identified; of these 33 were lentiginous, 10 nested and 18 both lentiginous and nested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We propose that the three distinct patterns of follicular involvement by invasive melanoma and the three distinct patterns of <jats:styled-content style=\"fixed-case\">MIS<\/jats:styled-content> will be valuable for logically categorizing involvement of the hair follicle by melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12851","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T08:36:50Z","timestamp":1477384610000},"page":"45-52","source":"Crossref","is-referenced-by-count":14,"title":["A proposed classification for follicular involvement by melanoma"],"prefix":"10.1111","volume":"44","author":[{"given":"B. Joel","family":"Tjarks","sequence":"first","affiliation":[{"name":"Department of Pathology University of South Dakota \u2013 Sanford School of Medicine  Sioux Falls SD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najwa","family":"Somani","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cleveland Clinic  Cleveland OH USA"},{"name":"Department of Dermatology Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Piliang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma F.","family":"Bergfeld","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24117"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200410000-00002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000087"},{"key":"e_1_2_6_5_1","first-page":"AB131","article-title":"Metastatic folliculotropic melanoma: a unique presentation of melanoma","volume":"60","author":"Somani N","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.06.046"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01827.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.12.033"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31827a0bfb"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1093"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31829d7f35"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.7.871"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199612000-00002"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.020933"},{"key":"e_1_2_6_15_1","first-page":"630","article-title":"Differences in latency and inducibility of mouse skin melanomas depending on the age and anatomic site of the skin","volume":"58","author":"Silvers WK","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197011000-00017"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.5858\/2010-0229-RAR.1"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:36:05Z","timestamp":1696336565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,24]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/cup.12851"],"URL":"https:\/\/doi.org\/10.1111\/cup.12851","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,24]]}}}