{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:36:23Z","timestamp":1771662983559,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T00:00:00Z","timestamp":1482364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The lipogenic pathway is upregulated in cancer cells, including melanomas. However, the pathological significance of cellular lipids in melanocytic lesions has yet to be determined. In this study, we evaluated intracytoplasmic lipid droplets in melanocytic nevi (<jats:styled-content style=\"fixed-case\">MNs<\/jats:styled-content>) and malignant melanomas via immunohistochemical analysis of adipophilin (<jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content>), which coats lipid droplets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred primary cutaneous melanocytic lesions [33 <jats:styled-content style=\"fixed-case\">MNs<\/jats:styled-content>, 17 melanomas <jats:italic>in situ<\/jats:italic> (<jats:styled-content style=\"fixed-case\">MIS<\/jats:styled-content>), and 50 invasive melanomas (<jats:styled-content style=\"fixed-case\">IMs<\/jats:styled-content>)] were immunostained for <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content>. The intensity score (<jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content>) and proportion score (<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>) of <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content> staining in each case was recorded semiquantitatively on a scale of 0 to 3+.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content> expression (<jats:styled-content style=\"fixed-case\">IS2<\/jats:styled-content>\/3+ and <jats:styled-content style=\"fixed-case\">PS2<\/jats:styled-content>\/3+) was observed in 27 primary cutaneous melanocytic lesions that consisted of 23 <jats:styled-content style=\"fixed-case\">IMs<\/jats:styled-content>, three <jats:styled-content style=\"fixed-case\">MISs<\/jats:styled-content>, and one <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content>. Consequently, high <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content> expression was associated with malignancy (38.8% vs. 3.0%; p &lt; 0.0001). Among the <jats:styled-content style=\"fixed-case\">IMs<\/jats:styled-content>, high <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content> expression was more prevalent in <jats:styled-content style=\"fixed-case\">pT3<\/jats:styled-content>\/4 than <jats:styled-content style=\"fixed-case\">pT1<\/jats:styled-content>\/2 (63.3% vs. 23.8%; p = 0.01) and Stage 3\/4 than Stage 1\/2 (76.9% vs. 36.8%; p = 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of the melanocytic lesions with high <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content> expression were malignant melanomas in our cohort. Therefore, <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content> expression may serve as a sensitive diagnostic marker for malignant melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12868","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T12:52:56Z","timestamp":1480078376000},"page":"228-236","source":"Crossref","is-referenced-by-count":23,"title":["Adipophilin expression in cutaneous malignant melanoma"],"prefix":"10.1111","volume":"44","author":[{"given":"Masakazu","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibu","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Warigaya","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Iwahashi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiyoshi","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fukumi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010ichi","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,22]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"419","article-title":"PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores","volume":"2009","author":"Bickel PE","year":"1791","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.08.026"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.033381"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.191"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.02.003"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2222"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13048"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80121-1"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.188"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000255"},{"key":"e_1_2_5_13_1","volume-title":"TNM classification of malignant tumours","author":"Sobin LH","year":"2009"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31821a7f3e"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2003.300104.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800395"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.157"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.355"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.1"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000275"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20120082"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.70"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181b94f3c"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800281"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:11:55Z","timestamp":1696356715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,22]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/cup.12868"],"URL":"https:\/\/doi.org\/10.1111\/cup.12868","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,22]]}}}