{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:19:32Z","timestamp":1778498372292,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:00:00Z","timestamp":1485302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Distinguishing primary cutaneous adnexal carcinoma from metastatic carcinoma of unknown primary can be a diagnostic challenge due to the frequent overlap of histologic and immunohistochemical features. A 58\u2010year\u2010old man presented with a tender, indurated plaque on axillary skin. Biopsy revealed infiltrating atypical cells throughout the dermis, without connection to the epidermis. Tumor cells had a histiocytoid appearance and displayed mild pleomorphism. The tumor was discohesive and had areas with a single file pattern. Signet ring cells were also present. Cells were reactive with <jats:styled-content style=\"fixed-case\">CK7<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CK5<\/jats:styled-content>\/6, p63, <jats:styled-content style=\"fixed-case\">GATA3<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">GCDFP<\/jats:styled-content>\u201015 and Her 2\u2010neu. Additional studies were negative, including <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">CDX2<\/jats:styled-content>, E\u2010cadherin, mammaglobin, <jats:styled-content style=\"fixed-case\">estrogen receptor<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">progesterone receptor<\/jats:styled-content>. Thorough clinical and radiologic evaluation failed to identify an occult primary extracutaneous malignancy; however, regional lymphadenopathy, widespread osteoblastic lesions and multiple subcentimeter liver hypodensities were noted. Considering the clinical and histopathologic features, the diagnosis of primary cutaneous histiocytoid carcinoma with distant metastasis was favored.<\/jats:p>","DOI":"10.1111\/cup.12875","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T06:22:42Z","timestamp":1482301362000},"page":"376-380","source":"Crossref","is-referenced-by-count":8,"title":["Primary cutaneous histiocytoid carcinoma with distant metastasis"],"prefix":"10.1111","volume":"44","author":[{"given":"Rebecca","family":"Philips","sequence":"first","affiliation":[{"name":"Department of Dermatology The University of Texas Medical Branch  Galveston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Langston","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Texas Medical Branch  Galveston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas Southwestern  Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-3838","authenticated-orcid":false,"given":"Travis","family":"Vandergriff","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Texas Southwestern  Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Trynosky","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Texas Medical Branch  Galveston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma C.","family":"Berlingeri\u2010Ramos","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Texas Medical Branch  Galveston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,25]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318209cac7"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(97)80031-3"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12061"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.04.039"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199902000-00009"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04106.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20889"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181590ba4"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00207.x"},{"key":"e_1_2_4_11_1","volume-title":"McKee's Pathology of the Skin: With Clinical Correlations","author":"Calonje E","year":"2012"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP2N1AFXEFOVYE"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.01.006"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2010.02.008"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800007"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2012.01561.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.12875","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:09:26Z","timestamp":1694426966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,25]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/cup.12875"],"URL":"https:\/\/doi.org\/10.1111\/cup.12875","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,25]]}}}