{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:31:57Z","timestamp":1763663517407},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Distinguishing regressed lichen planus\u2010like keratosis (<jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content>) from regressed melanoma can be difficult on histopathologic examination, potentially resulting in mismanagement of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to identify histopathologic features by which regressed melanoma can be differentiated from regressed <jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty actively inflamed <jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content>, 12 <jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content> with regression and 15 melanomas with regression were compared and evaluated by hematoxylin and eosin staining as well as Melan\u2010A, microphthalmia transcription factor (<jats:styled-content style=\"fixed-case\">MiTF<\/jats:styled-content>) and cytokeratin (<jats:styled-content style=\"fixed-case\">AE1<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AE3<\/jats:styled-content>) immunostaining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(1) A total of 40% of regressed melanomas showed complete or near complete loss of melanocytes within the epidermis with Melan\u2010A and <jats:styled-content style=\"fixed-case\">MiTF<\/jats:styled-content> immunostaining, while 8% of regressed <jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content> exhibited this finding. (2) Necrotic keratinocytes were seen in the epidermis in 33% regressed melanomas as opposed to all of the regressed <jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content>. (3) A dense infiltrate of melanophages in the papillary dermis was seen in 40% of regressed melanomas, a feature not seen in regressed <jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, our findings suggest that a complete or near complete loss of melanocytes within the epidermis strongly favors a regressed melanoma over a regressed <jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content>. In addition, necrotic epidermal keratinocytes and the presence of a dense band\u2010like distribution of dermal melanophages can be helpful in differentiating these lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12879","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T13:13:20Z","timestamp":1482844400000},"page":"338-341","source":"Crossref","is-referenced-by-count":8,"title":["Differentiating regressed melanoma from regressed lichenoid keratosis"],"prefix":"10.1111","volume":"44","author":[{"given":"Aegean H.","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Dermatology Albert Einstein College of Medicine  Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J.","family":"Shulman","sequence":"additional","affiliation":[{"name":"Dermpath Diagnostics  Port Chester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Dermatology Albert Einstein College of Medicine  Bronx New York"},{"name":"Ackerman Academy of Dermatopathology Dermpath Diagnostics  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Weedon's Skin Pathology","author":"Patterson JW","year":"2016"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000175533.65486.84"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1992.tb00988.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/JDY7-M43Y-J3JU-DW57"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(03)00234-X"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31821bbfe2"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31819d3769"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0202a08"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33183.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.02.039"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.20755.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000205"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107236"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.42"},{"issue":"8","key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.4049\/jimmunol.154.8.3961","article-title":"Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor\u2010infiltrating T lymphocytes associated with in vivo tumor regression","volume":"154","author":"Kawakami Y","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2015.03.001"},{"issue":"2","key":"e_1_2_5_18_1","first-page":"359","article-title":"The many faces of completely regressed malignant melanoma","volume":"2","author":"Barr RJ","year":"1994","journal-title":"Pathology (Phila)"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07370.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199804000-00002"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.12879","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:08:57Z","timestamp":1694426937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/cup.12879"],"URL":"https:\/\/doi.org\/10.1111\/cup.12879","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,2]]}}}