{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:47:12Z","timestamp":1787615232351,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Angiolymphoid hyperplasia with eosinophilia (<jats:styled-content style=\"fixed-case\">ALHE<\/jats:styled-content>) is a poorly understood benign vasculoproliferative disorder. Histopathologically, the lesions are composed of a dermal or subcutaneous proliferation of blood vessels of varying sizes with plump and bland endothelial cells, which often show vacuolization and protrusion of the cytoplasm into the lumen. The vascular proliferation is admixed with a diffuse inflammatory infiltrate composed of lymphocytes, eosinophils and mast cells. Lymphoid follicles with germinal centers can sometimes be seen. In addition, fibrosis is a common accompanying feature. Some clinical and histopathological variants of <jats:styled-content style=\"fixed-case\">ALHE<\/jats:styled-content> have already been described in the literature. In this report, we present 3 rare associations of <jats:styled-content style=\"fixed-case\">ALHE<\/jats:styled-content> that have not been previously described. Case 1 was a 73\u2010year\u2010old woman with a lesion on her right medial thigh. Examination showed <jats:styled-content style=\"fixed-case\">ALHE<\/jats:styled-content> admixed with a chronic lymphocytic leukemic (<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>) infiltrate. Case 2 was a 55\u2010year\u2010old woman with a lesion on her right anterior ankle, which was a syringocystadenoma papilliferum co\u2010existing with an <jats:styled-content style=\"fixed-case\">ALHE<\/jats:styled-content>. Case 3 was a 54\u2010year\u2010old man with a lesion on the left medial thigh, which showed overlapping features of <jats:styled-content style=\"fixed-case\">IgG4<\/jats:styled-content>\u2010related disease associated with areas of <jats:styled-content style=\"fixed-case\">ALHE<\/jats:styled-content>. Given these multiple and diverse associations, it seems likely that <jats:styled-content style=\"fixed-case\">ALHE<\/jats:styled-content> may be a reactive rather than neoplastic process.<\/jats:p>","DOI":"10.1111\/cup.12886","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T06:22:38Z","timestamp":1483078958000},"page":"300-306","source":"Crossref","is-referenced-by-count":15,"title":["Three unusual histopathological presentations of angiolymphoid hyperplasia with eosinophilia"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-2364","authenticated-orcid":false,"given":"Angel","family":"Fernandez\u2010Flores","sequence":"first","affiliation":[{"name":"Cellular Pathology Hospital El Bierzo  Ponferrada Spain"},{"name":"CellCOM\u2010ST Group Biomedical Investigation Institute of A Coru\u00f1a  A Coru\u00f1a Spain"},{"name":"Cellular Pathology Hospital de la Reina  Ponferrada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8875-0858","authenticated-orcid":false,"given":"David S.","family":"Cassarino","sequence":"additional","affiliation":[{"name":"Department of Pathology Southern California Kaiser Permanente, Los Angeles Medical Center (LAMC), Kaiser Permanente  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70098-9"},{"issue":"3","key":"e_1_2_4_3_1","doi-asserted-by":"crossref","DOI":"10.5070\/D3203021755","article-title":"Angiolymphoid hyperplasia with eosinophilia of the infra\u2010axillary region: report of a case","volume":"20","author":"Parmar NV","year":"2014","journal-title":"Dermatol Online J"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.8243"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.125352"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193413513986"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.119757"},{"issue":"9","key":"e_1_2_4_8_1","first-page":"E10","article-title":"An unusual case of angiolymphoid hyperplasia with eosinophilia of the nose","volume":"92","author":"Chiu SC","year":"2013","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00020-3"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04133.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1969.tb15914.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.100501"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08733.x"},{"issue":"10","key":"e_1_2_4_14_1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1001\/archderm.1981.01650100052028","article-title":"Angiolymphoid hyperplasia with eosinophilia (Kimura's disease). 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