{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:03:22Z","timestamp":1783001002472,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Superimposed infections\/sepsis are the major cause of morbidity\/mortality in Stevens\u2013Johnson syndrome\/Toxic Epidermal Necrolysis (<jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>). It is a delicate balance between avoiding new pharmaceuticals and prophylactically treat an incipient infection. The objective of this study was to investigate the rates and types of infection\u2010microbials and antibiotics involved in <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Microbiology and clinical data were collected for <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> patients admitted to our Burn Center from January 2010 through January 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 24 patients were admitted over the study period. There were 303 bacterial cultures taken whereof 113 (37.3%) were positive (median of 4.4 per patient). Twenty\u2010two (91.7%) patients had at least 1 positive sample recorded. Fifteen (62.5%) patients had a confirmed episode of sepsis with skin being the most common source of colonization (77.8%). Eleven (45.8%) patients received empiric antibiotic therapy at referral facility\/prior to admission to our Center. Patients who grew a higher number of different species were significantly less likely to have received early empiric antimicrobial therapy (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Secondary bacterial infection and sepsis were a highly common finding in our patient population. Despite the risk of resistance and further immunological provocation, empirical antibiotic treatment might have a place in clinical management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12894","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T12:33:18Z","timestamp":1484137998000},"page":"420-432","source":"Crossref","is-referenced-by-count":17,"title":["Microbiological findings and antibacterial therapy in Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis patients from a Swedish Burn Center"],"prefix":"10.1111","volume":"44","author":[{"given":"Ilaria","family":"Tocco\u2010Tussardi","sequence":"first","affiliation":[{"name":"Uppsala Burn Centre, Department of Plastic and Maxillofacial Surgery Uppsala University Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Huss","sequence":"additional","affiliation":[{"name":"Uppsala Burn Centre, Department of Plastic and Maxillofacial Surgery Uppsala University Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Presman","sequence":"additional","affiliation":[{"name":"Uppsala Burn Centre, Department of Plastic and Maxillofacial Surgery Uppsala University Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1956.tb12766.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670250049006"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701033"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06721.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311906"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29025.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660330071012"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00061.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03826.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000062"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200209010-00008"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-200021030-00004"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02082.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04143.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2016.01.034"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-200203000-00004"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199809020-00014"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.01.025"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181ca4290"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762005000500014"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(02)00285-1"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.09.017"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-199405000-00006"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1986.01400060043004"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.3.323"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(00)00136-4"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70333-D"},{"key":"e_1_2_5_30_1","doi-asserted-by":"crossref","unstructured":"Gerdts B Vloemans AF Kreis RW. 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